Unveiling the crucial role of CD8+ T cell and endothelial cell interaction in rheumatoid arthritis through the integrated analysis of spatial transcriptomics and bulk/single-cell RNA-seq

Unveiling the crucial role of CD8+ T cell and endothelial cell interaction in rheumatoid arthritis through the integrated analysis of spatial transcriptomics and bulk/single-cell RNA-seq

Background: Rheumatoid arthritis (RA) is a prevalent chronic autoimmune disease. While the chemokine signaling pathway plays a pivotal role in RA pathogenesis, the specific cellular interactions remain unclear. Methods: A three-stage analytical framework was implemented. First, to uncover crucial si...

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Bibliographic Details
Main Authors: Yu Lai, Zishao Zhong, Runze Li, Tuliang Liang, Xizi He, Yuan Liu, Hao Yu, Chuanhai Zhang, Yao Xiao, Liang Liu, Hudan Pan
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Translational Autoimmunity
Subjects:
Rheumatoid arthritis
Single-cell RNA sequencing
Spatial transcriptome sequencing
CD8+ T cells
Endothelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909025000206
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