Evaluation of cytotoxicity effects of oleo-gum-resin and its essential oil of Ferula assa-foetida and ferulic acid on 4T1 breast cancer cells
Background: Cancer causes significant morbidity and mortality and is a major public health problem worldwide. Breast cancer is a leading cause of cancer-associated mortality in women, and the incidence is also on the rise in the entire world. Medicinal plants have been an important source of several...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2017-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=2;spage=116;epage=120;aulast=Bagheri |
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| author | Seyyed Majid Bagheri Amir Abdian Asl Ali Shams Seyyed Ali Mirghanizadeh-Bafghi Zeynab Hafizibarjin |
| author_facet | Seyyed Majid Bagheri Amir Abdian Asl Ali Shams Seyyed Ali Mirghanizadeh-Bafghi Zeynab Hafizibarjin |
| author_sort | Seyyed Majid Bagheri |
| collection | DOAJ |
| description | Background: Cancer causes significant morbidity and mortality and is a major public health problem worldwide. Breast cancer is a leading cause of cancer-associated mortality in women, and the incidence is also on the rise in the entire world. Medicinal plants have been an important source of several clinically useful anticancer agents. Aim: In this study, we studied the growth inhibitory effect of asafoetida and its essential oil and ferulic acid on antitumor activity using mouse breast cancer cell line. Materials and Methods: For this aim, cells were exposed to these components at different concentrations and for different time durations. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was carried out to characterize the cytotoxicity of the constituents used. Results: Our results showed that all three constituents could inhibit 4T1 cell proliferation. Our MTT assay results showed a significant cytotoxicity effect in a time- and concentration-dependent manner. It also demonstrated that essential oil of asafoetida has a stronger effect in decreasing viability breast cancer cells. Ferulic acid showed a significant effect only at a dose of 500 μg/ml. Conclusions: Based on the results of cellular carried out in this study, we could demonstrate that asafoetida and its essential oil and ferulic acid have inhibitory effect on the growth of breast cancer cell line. As evidenced from these preliminary results, asafoetida and its derivative constituents may be considered as attractive alternatives to serve as lead compounds in drug development for breast cancer as an adjuvant therapy. However, much remains to be done before such agent could be introduced to the clinic. |
| format | Article |
| id | doaj-art-0fcc7802e4524542baa90ee5db4bfe54 |
| institution | OA Journals |
| issn | 0971-5851 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-0fcc7802e4524542baa90ee5db4bfe542025-08-20T02:02:32ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512017-01-0138211612010.4103/ijmpo.ijmpo_60_16Evaluation of cytotoxicity effects of oleo-gum-resin and its essential oil of Ferula assa-foetida and ferulic acid on 4T1 breast cancer cellsSeyyed Majid BagheriAmir Abdian AslAli ShamsSeyyed Ali Mirghanizadeh-BafghiZeynab HafizibarjinBackground: Cancer causes significant morbidity and mortality and is a major public health problem worldwide. Breast cancer is a leading cause of cancer-associated mortality in women, and the incidence is also on the rise in the entire world. Medicinal plants have been an important source of several clinically useful anticancer agents. Aim: In this study, we studied the growth inhibitory effect of asafoetida and its essential oil and ferulic acid on antitumor activity using mouse breast cancer cell line. Materials and Methods: For this aim, cells were exposed to these components at different concentrations and for different time durations. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was carried out to characterize the cytotoxicity of the constituents used. Results: Our results showed that all three constituents could inhibit 4T1 cell proliferation. Our MTT assay results showed a significant cytotoxicity effect in a time- and concentration-dependent manner. It also demonstrated that essential oil of asafoetida has a stronger effect in decreasing viability breast cancer cells. Ferulic acid showed a significant effect only at a dose of 500 μg/ml. Conclusions: Based on the results of cellular carried out in this study, we could demonstrate that asafoetida and its essential oil and ferulic acid have inhibitory effect on the growth of breast cancer cell line. As evidenced from these preliminary results, asafoetida and its derivative constituents may be considered as attractive alternatives to serve as lead compounds in drug development for breast cancer as an adjuvant therapy. However, much remains to be done before such agent could be introduced to the clinic.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=2;spage=116;epage=120;aulast=Bagheri4T1 cell lineasafoetidabreast canceressential oilferulic acid |
| spellingShingle | Seyyed Majid Bagheri Amir Abdian Asl Ali Shams Seyyed Ali Mirghanizadeh-Bafghi Zeynab Hafizibarjin Evaluation of cytotoxicity effects of oleo-gum-resin and its essential oil of Ferula assa-foetida and ferulic acid on 4T1 breast cancer cells Indian Journal of Medical and Paediatric Oncology 4T1 cell line asafoetida breast cancer essential oil ferulic acid |
| title | Evaluation of cytotoxicity effects of oleo-gum-resin and its essential oil of Ferula assa-foetida and ferulic acid on 4T1 breast cancer cells |
| title_full | Evaluation of cytotoxicity effects of oleo-gum-resin and its essential oil of Ferula assa-foetida and ferulic acid on 4T1 breast cancer cells |
| title_fullStr | Evaluation of cytotoxicity effects of oleo-gum-resin and its essential oil of Ferula assa-foetida and ferulic acid on 4T1 breast cancer cells |
| title_full_unstemmed | Evaluation of cytotoxicity effects of oleo-gum-resin and its essential oil of Ferula assa-foetida and ferulic acid on 4T1 breast cancer cells |
| title_short | Evaluation of cytotoxicity effects of oleo-gum-resin and its essential oil of Ferula assa-foetida and ferulic acid on 4T1 breast cancer cells |
| title_sort | evaluation of cytotoxicity effects of oleo gum resin and its essential oil of ferula assa foetida and ferulic acid on 4t1 breast cancer cells |
| topic | 4T1 cell line asafoetida breast cancer essential oil ferulic acid |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2017;volume=38;issue=2;spage=116;epage=120;aulast=Bagheri |
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