Hemostatic system changes predictive value in patients with ischemic brain disorders
The aim of this research was to determine the importance of tracking the dynamics of changes of the hemostatic system factors (aggregation of thrombocytes, D-dimer, PAI-1, antithrombin III, protein C and protein S, factor VII and factor VIII, fibrin degradation products, euglobulin test and the acti...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2002-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2002/0042-84500204377R.pdf |
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| _version_ | 1850234773480407040 |
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| author | Raičević Ranko Jovičić Aco Mandić-Radić Slavka Đorđević Dragana Magdić Bratislav Marković Ljubo Veljančić Dragana Dinčić Evica Obradović Slobodan |
| author_facet | Raičević Ranko Jovičić Aco Mandić-Radić Slavka Đorđević Dragana Magdić Bratislav Marković Ljubo Veljančić Dragana Dinčić Evica Obradović Slobodan |
| author_sort | Raičević Ranko |
| collection | DOAJ |
| description | The aim of this research was to determine the importance of tracking the dynamics of changes of the hemostatic system factors (aggregation of thrombocytes, D-dimer, PAI-1, antithrombin III, protein C and protein S, factor VII and factor VIII, fibrin degradation products, euglobulin test and the activated partial thromboplastin time – aPTPV) in relation to the level of the severity of ischemic brain disorders (IBD) and the level of neurological and functional deficiency in the beginning of IBD manifestation from 7 to 10 days, 19 to 21 day, and after 3 to 6 months. The research results confirmed significant predictive value of changes of hemostatic system with the predomination of procoagulant factors, together with the insufficiency of fibrinolysis. Concerning the IBD severity and it's outcome, the significant predictive value was shown in the higher levels of PAI-1 and the lower level of antithrombin III, and borderline significant value was shown in the accelerated aggregation of thrombocytes and the increased concentration of D-dimer. It could be concluded that the tracking of the dynamics of changes in parameters of hemostatic system proved to be an easily accessible method with the significant predictive value regarding the development of more severe. IBD cases and the outcome of the disease itself. |
| format | Article |
| id | doaj-art-0fcb1d1476e54fec9f0a8219d3f7b068 |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-0fcb1d1476e54fec9f0a8219d3f7b0682025-08-20T02:02:32ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502002-01-0159437738410.2298/VSP0204377RHemostatic system changes predictive value in patients with ischemic brain disordersRaičević RankoJovičić AcoMandić-Radić SlavkaĐorđević DraganaMagdić BratislavMarković LjuboVeljančić DraganaDinčić EvicaObradović SlobodanThe aim of this research was to determine the importance of tracking the dynamics of changes of the hemostatic system factors (aggregation of thrombocytes, D-dimer, PAI-1, antithrombin III, protein C and protein S, factor VII and factor VIII, fibrin degradation products, euglobulin test and the activated partial thromboplastin time – aPTPV) in relation to the level of the severity of ischemic brain disorders (IBD) and the level of neurological and functional deficiency in the beginning of IBD manifestation from 7 to 10 days, 19 to 21 day, and after 3 to 6 months. The research results confirmed significant predictive value of changes of hemostatic system with the predomination of procoagulant factors, together with the insufficiency of fibrinolysis. Concerning the IBD severity and it's outcome, the significant predictive value was shown in the higher levels of PAI-1 and the lower level of antithrombin III, and borderline significant value was shown in the accelerated aggregation of thrombocytes and the increased concentration of D-dimer. It could be concluded that the tracking of the dynamics of changes in parameters of hemostatic system proved to be an easily accessible method with the significant predictive value regarding the development of more severe. IBD cases and the outcome of the disease itself.http://www.doiserbia.nb.rs/img/doi/0042-8450/2002/0042-84500204377R.pdfcerebrovascular disordersbrain ischemiahemostasisneurologic examinationblood plateletsplatelet aggregationhemorheology |
| spellingShingle | Raičević Ranko Jovičić Aco Mandić-Radić Slavka Đorđević Dragana Magdić Bratislav Marković Ljubo Veljančić Dragana Dinčić Evica Obradović Slobodan Hemostatic system changes predictive value in patients with ischemic brain disorders Vojnosanitetski Pregled cerebrovascular disorders brain ischemia hemostasis neurologic examination blood platelets platelet aggregation hemorheology |
| title | Hemostatic system changes predictive value in patients with ischemic brain disorders |
| title_full | Hemostatic system changes predictive value in patients with ischemic brain disorders |
| title_fullStr | Hemostatic system changes predictive value in patients with ischemic brain disorders |
| title_full_unstemmed | Hemostatic system changes predictive value in patients with ischemic brain disorders |
| title_short | Hemostatic system changes predictive value in patients with ischemic brain disorders |
| title_sort | hemostatic system changes predictive value in patients with ischemic brain disorders |
| topic | cerebrovascular disorders brain ischemia hemostasis neurologic examination blood platelets platelet aggregation hemorheology |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2002/0042-84500204377R.pdf |
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