Comparative study of chitosan-based liquid dressing and recombinant human epidermal growth factor on acute limb skin wound healing: A randomized controlled trial
Abstracts: Background: Several traditional dressings may have limitation in treating wounds. A novel chitosan-based dressing designed for improved hemostasis, moisture, and sealing shows promise in wound healing. However, its efficacy and safety are yet to be sufficiently verified in patients. Meth...
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Elsevier
2025-06-01
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| Series: | JPRAS Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352587825000622 |
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| author | Dunyong Tan Jiawei Guo Xiaoqiang Chen Jianquan Liu Siyao Yang Daping Wang Wencui Li |
| author_facet | Dunyong Tan Jiawei Guo Xiaoqiang Chen Jianquan Liu Siyao Yang Daping Wang Wencui Li |
| author_sort | Dunyong Tan |
| collection | DOAJ |
| description | Abstracts: Background: Several traditional dressings may have limitation in treating wounds. A novel chitosan-based dressing designed for improved hemostasis, moisture, and sealing shows promise in wound healing. However, its efficacy and safety are yet to be sufficiently verified in patients. Methods: This randomized controlled trial enrolled 40 patients suffering from acute skin wounds in the limbs from 12/2022 to 12/2023. They were randomly divided into two groups (20 vs. 20) and received regular treatments in the Shenzhen Second People's Hospital. The experimental group was treated with chitosan-based liquid dressing, whereas the control group was treated with traditional dressing with recombinant human epidermal growth factor (rhEGF). The therapeutic effects (scar area and pigment deposition), adverse events, visual analogue scale (VAS), healing time, cost, and the patient and observer scar assessment scale (POSAS) were evaluated on days 0, 7, 14, and 28. Results: No adverse events were observed throughout the trial. On day 28, effective rate between groups were not statistically significant between the groups (70% vs. 85%, p = 0.256). Other parameters that were not significant included VAS (5.10 ± 1.62 vs. 6.35 ± 2.39, p = 0.06), healing time (8.45 ± 4.26 vs. 8.60 ± 5.44 days, p = 0.923), and cost (49.00 ± 22.48 vs. 57.40 ± 27.59, p = 0.298). However, on day 28, the patient- and observer-reported SAS of the chitosan (CS) group was significantly lower than that of the rhEGF group (12.00 vs. 9.50, z = 2.477, p = 0.013; 18.50 vs. 12.50, z = 2.209, p = 0.026; respectively), and the total POSAS (30.50 vs. 22.00, z = 2.374, p = 0.017). Conclusion: Compared to rhEGF, the CS-based liquid dressing showed reliable safety and equivalent performance in treating acute limb skin wounds, as revealed by improvements in healing time and rate, pain relief, and costs. Moreover, liquid dressing significantly reduced scar formation, indicating its potential in wound therapy. |
| format | Article |
| id | doaj-art-0fca7d344ee1418cbbf704b0f0a4d611 |
| institution | DOAJ |
| issn | 2352-5878 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| series | JPRAS Open |
| spelling | doaj-art-0fca7d344ee1418cbbf704b0f0a4d6112025-08-20T03:13:29ZengElsevierJPRAS Open2352-58782025-06-014437938910.1016/j.jpra.2025.03.018Comparative study of chitosan-based liquid dressing and recombinant human epidermal growth factor on acute limb skin wound healing: A randomized controlled trialDunyong Tan0Jiawei Guo1Xiaoqiang Chen2Jianquan Liu3Siyao Yang4Daping Wang5Wencui Li6Department of Hand and Foot Surgery, Shenzhen Second People’ s Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, Guangdong, 518028, ChinaDepartment of Hand and Foot Surgery, Shenzhen Second People’ s Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, Guangdong, 518028, China; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, ChinaDepartment of Hand and Foot Surgery, Shenzhen Second People’ s Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, Guangdong, 518028, ChinaDepartment of Hand and Foot Surgery, Shenzhen Second People’ s Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, Guangdong, 518028, ChinaThe Medical Record Department, Shenzhen Second People’ s Hospital, Shenzhen, Guangdong, 518028, ChinaDepartment of Hand and Foot Surgery, Shenzhen Second People’ s Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, Guangdong, 518028, China; Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China; Corresponding author. Daping Wang, Shenzhen Second People's Hospital, 3002 Sungang West Road, Shenzhen 518028, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, Tel.: +86-0755-83366388, Fax: +86-0755-83366388.Department of Hand and Foot Surgery, Shenzhen Second People’ s Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, Guangdong, 518028, China; Wencui Li, Shenzhen Second People's Hospital, 3002 Sungang West Road, Shenzhen 518028, Tel.: +86-0755-83366388, Fax: +86-0755-83366388.Abstracts: Background: Several traditional dressings may have limitation in treating wounds. A novel chitosan-based dressing designed for improved hemostasis, moisture, and sealing shows promise in wound healing. However, its efficacy and safety are yet to be sufficiently verified in patients. Methods: This randomized controlled trial enrolled 40 patients suffering from acute skin wounds in the limbs from 12/2022 to 12/2023. They were randomly divided into two groups (20 vs. 20) and received regular treatments in the Shenzhen Second People's Hospital. The experimental group was treated with chitosan-based liquid dressing, whereas the control group was treated with traditional dressing with recombinant human epidermal growth factor (rhEGF). The therapeutic effects (scar area and pigment deposition), adverse events, visual analogue scale (VAS), healing time, cost, and the patient and observer scar assessment scale (POSAS) were evaluated on days 0, 7, 14, and 28. Results: No adverse events were observed throughout the trial. On day 28, effective rate between groups were not statistically significant between the groups (70% vs. 85%, p = 0.256). Other parameters that were not significant included VAS (5.10 ± 1.62 vs. 6.35 ± 2.39, p = 0.06), healing time (8.45 ± 4.26 vs. 8.60 ± 5.44 days, p = 0.923), and cost (49.00 ± 22.48 vs. 57.40 ± 27.59, p = 0.298). However, on day 28, the patient- and observer-reported SAS of the chitosan (CS) group was significantly lower than that of the rhEGF group (12.00 vs. 9.50, z = 2.477, p = 0.013; 18.50 vs. 12.50, z = 2.209, p = 0.026; respectively), and the total POSAS (30.50 vs. 22.00, z = 2.374, p = 0.017). Conclusion: Compared to rhEGF, the CS-based liquid dressing showed reliable safety and equivalent performance in treating acute limb skin wounds, as revealed by improvements in healing time and rate, pain relief, and costs. Moreover, liquid dressing significantly reduced scar formation, indicating its potential in wound therapy.http://www.sciencedirect.com/science/article/pii/S2352587825000622Wound HealingChitosanEGFScar |
| spellingShingle | Dunyong Tan Jiawei Guo Xiaoqiang Chen Jianquan Liu Siyao Yang Daping Wang Wencui Li Comparative study of chitosan-based liquid dressing and recombinant human epidermal growth factor on acute limb skin wound healing: A randomized controlled trial JPRAS Open Wound Healing Chitosan EGF Scar |
| title | Comparative study of chitosan-based liquid dressing and recombinant human epidermal growth factor on acute limb skin wound healing: A randomized controlled trial |
| title_full | Comparative study of chitosan-based liquid dressing and recombinant human epidermal growth factor on acute limb skin wound healing: A randomized controlled trial |
| title_fullStr | Comparative study of chitosan-based liquid dressing and recombinant human epidermal growth factor on acute limb skin wound healing: A randomized controlled trial |
| title_full_unstemmed | Comparative study of chitosan-based liquid dressing and recombinant human epidermal growth factor on acute limb skin wound healing: A randomized controlled trial |
| title_short | Comparative study of chitosan-based liquid dressing and recombinant human epidermal growth factor on acute limb skin wound healing: A randomized controlled trial |
| title_sort | comparative study of chitosan based liquid dressing and recombinant human epidermal growth factor on acute limb skin wound healing a randomized controlled trial |
| topic | Wound Healing Chitosan EGF Scar |
| url | http://www.sciencedirect.com/science/article/pii/S2352587825000622 |
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