Comorbidities and anthropometric parameters in obstructive sleep apnea syndrome: a phenotype-based study
Purpose Obstructive Sleep Apnea Syndrome (OSAS) is a heterogeneous syndrome and shows different phenotypic, clinical and physiopathological features. The aim of this study was to examine the relationships between OSAS phenotypes and comorbidities and anthropometric measurements and to identify OSAS...
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Taylor & Francis Group
2025-12-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10641963.2025.2512136 |
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| author | Mihrican Yeşildağ Faysal Duksal |
| author_facet | Mihrican Yeşildağ Faysal Duksal |
| author_sort | Mihrican Yeşildağ |
| collection | DOAJ |
| description | Purpose Obstructive Sleep Apnea Syndrome (OSAS) is a heterogeneous syndrome and shows different phenotypic, clinical and physiopathological features. The aim of this study was to examine the relationships between OSAS phenotypes and comorbidities and anthropometric measurements and to identify OSAS phenotypes that should be referred for early diagnosis and treatment.Materials and Methods We retrospectively reviewed 600 patients who underwent polysomnography (PSG) in our sleep center. Seven phenotypes were defined as Simple Snoring (SS)-Control, Mild, Moderate and Severe OSAS, Rem Dependent OSAS (RDO), Position Dependent OSAS (PDO) and Rem+Position dependent OSAS (R+PDO). Demographic data, anthropometric measurements and comorbid diseases of the patients were obtained retrospectively from their files. OSAS phenotypes were compared with comorbidities and anthropometric measurements.Results Severe OSAS was the most common phenotype. Oxygen desaturation index (ODI) and anthropometric measurements showed significant differences between phenotypes (p < .001). Hypertension (HT) (43.7%) and ischemic heart disease (CHD) (14.2%) were the most common comorbidities and were most commonly associated with severe OSAS. In logistic regression analysis, neck circumference (NC) and body mass index (BMI) were the anthropometric measures that predicted OSAS phenotypes. NC and BMI predicted severe OSAS, NC predicted PDO and R+PDO, and BMI predicted RDO.Conclusion This study revealed that OSAS phenotypes exhibit different clinical and anthropometric characteristics and differ in comorbidity risks. HT was found to be higher in severe OSAS, moderate OSAS and R+PDO, and CHD was higher in severe OSAS and RDO. Our study emphasized the importance of phenotypic characteristics as well as AHI in the management of comorbidities in OSAS. |
| format | Article |
| id | doaj-art-0fc99e06cf4a435f94d9037d452e7b22 |
| institution | DOAJ |
| issn | 1064-1963 1525-6006 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj-art-0fc99e06cf4a435f94d9037d452e7b222025-08-20T03:12:11ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062025-12-0147110.1080/10641963.2025.2512136Comorbidities and anthropometric parameters in obstructive sleep apnea syndrome: a phenotype-based studyMihrican Yeşildağ0Faysal Duksal1Department of Chest Diseases, Konya Meram State Hospital, Konya, TurkeyDepartment of Chest Diseases, University of Health Science, Konya Beyhekim Training and Research Hospital, Konya, TurkeyPurpose Obstructive Sleep Apnea Syndrome (OSAS) is a heterogeneous syndrome and shows different phenotypic, clinical and physiopathological features. The aim of this study was to examine the relationships between OSAS phenotypes and comorbidities and anthropometric measurements and to identify OSAS phenotypes that should be referred for early diagnosis and treatment.Materials and Methods We retrospectively reviewed 600 patients who underwent polysomnography (PSG) in our sleep center. Seven phenotypes were defined as Simple Snoring (SS)-Control, Mild, Moderate and Severe OSAS, Rem Dependent OSAS (RDO), Position Dependent OSAS (PDO) and Rem+Position dependent OSAS (R+PDO). Demographic data, anthropometric measurements and comorbid diseases of the patients were obtained retrospectively from their files. OSAS phenotypes were compared with comorbidities and anthropometric measurements.Results Severe OSAS was the most common phenotype. Oxygen desaturation index (ODI) and anthropometric measurements showed significant differences between phenotypes (p < .001). Hypertension (HT) (43.7%) and ischemic heart disease (CHD) (14.2%) were the most common comorbidities and were most commonly associated with severe OSAS. In logistic regression analysis, neck circumference (NC) and body mass index (BMI) were the anthropometric measures that predicted OSAS phenotypes. NC and BMI predicted severe OSAS, NC predicted PDO and R+PDO, and BMI predicted RDO.Conclusion This study revealed that OSAS phenotypes exhibit different clinical and anthropometric characteristics and differ in comorbidity risks. HT was found to be higher in severe OSAS, moderate OSAS and R+PDO, and CHD was higher in severe OSAS and RDO. Our study emphasized the importance of phenotypic characteristics as well as AHI in the management of comorbidities in OSAS.https://www.tandfonline.com/doi/10.1080/10641963.2025.2512136Anthropometric measurementscomorbiditiesphenotypesposition-dependent OSASrem-dependent OSAS |
| spellingShingle | Mihrican Yeşildağ Faysal Duksal Comorbidities and anthropometric parameters in obstructive sleep apnea syndrome: a phenotype-based study Clinical and Experimental Hypertension Anthropometric measurements comorbidities phenotypes position-dependent OSAS rem-dependent OSAS |
| title | Comorbidities and anthropometric parameters in obstructive sleep apnea syndrome: a phenotype-based study |
| title_full | Comorbidities and anthropometric parameters in obstructive sleep apnea syndrome: a phenotype-based study |
| title_fullStr | Comorbidities and anthropometric parameters in obstructive sleep apnea syndrome: a phenotype-based study |
| title_full_unstemmed | Comorbidities and anthropometric parameters in obstructive sleep apnea syndrome: a phenotype-based study |
| title_short | Comorbidities and anthropometric parameters in obstructive sleep apnea syndrome: a phenotype-based study |
| title_sort | comorbidities and anthropometric parameters in obstructive sleep apnea syndrome a phenotype based study |
| topic | Anthropometric measurements comorbidities phenotypes position-dependent OSAS rem-dependent OSAS |
| url | https://www.tandfonline.com/doi/10.1080/10641963.2025.2512136 |
| work_keys_str_mv | AT mihricanyesildag comorbiditiesandanthropometricparametersinobstructivesleepapneasyndromeaphenotypebasedstudy AT faysalduksal comorbiditiesandanthropometricparametersinobstructivesleepapneasyndromeaphenotypebasedstudy |