The factor XIa antibody osocimab strongly inhibits clotting in extracorporeal circuits with human blood and in baboons

The factor XIa antibody osocimab strongly inhibits clotting in extracorporeal circuits with human blood and in baboons

Background: Effective anticoagulant approaches in extracorporeal circuits with little impact on hemostasis are still an unmet medical need. Targeted inhibition of activated factor (F)XI might represent an attractive alternative or addition to conventional anticoagulation. Objectives: We aimed to eva...

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Bibliographic Details
Main Authors: Eslam Samaha, Michael Schwameis, Sabine Schranz, Katarina D. Kovacevic, Bruno Watschinger, Martin Stoiber, Christopher Wolf, Michael Wallisch, András Gruber, Erik I. Tucker, Anja Buchmüller, Bernd Jilma
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
anticoagulation
extracorporeal circuit
factor XIa inhibitor
monoclonal antibody
osocimab
Online Access:http://www.sciencedirect.com/science/article/pii/S2475037925002560
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