Chemotherapy-free innovations in locally advanced head and neck cancer: a comprehensive review

Chemotherapy-free innovations in locally advanced head and neck cancer: a comprehensive review

The treatment of locally advanced head and neck squamous cell carcinoma (LA-HNSCC) has traditionally relied on a multimodal approach, combining surgery, radiation therapy (RT), and chemotherapy. While chemotherapy plays a critical role in improving cure rates and functional outcomes, its substantial...

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Main Authors: Shatha Abu Taha, Taher Abu Hejleh, Mostafa ElHaddad, Akram Al-Ibraheem, Ahmed Abbasi, Abdulrahman Sumaida, Ahmad Bushehri, Ahmad Mostafa, Bassem Youssef, Ibrahim Alotain, Ibrahim Abu-Gheida, Mohammed Aldehaim, Majed Alghamdi, Mohamed Shelan, Mohammed Al Dohan, Maysa Al-Hussaini, Nadeem Pervez, Shoukri Temraz, Saad Alrashidi, Wael El-Sheshtawy, Zahid Al-Mandhari, Hamza Ghatasheh, Ali Hosni, Issa Mohamad
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oncology
Subjects:
head and neck cancer
concurrent chemoradiation
altered fractionation
immunotherapy
targeted therapy
hyperthermia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1552337/full
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