Prediction of drug concentrations in humans for long-acting injectable suspensions by a semi-mechanical muscle compartment model: a case study of paliperidone palmitate
Long-acting injectable formulations, such as paliperidone palmitate extended-release injectable suspension, have been designed to release medicines slowly and sustainably. Developing models that simulate drug release from long-acting injectable formulations in vivo is challenging. A novel approach t...
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| Main Authors: | Panpan Yu, Mengjun Zhang, Xiong Jin, Keheng Wu, Sihui Long, Shishi Cheng, Long Fu, Xiao Xu, Jie Liu, Dan Liu, Xue Li, Bo Liu, Jian Xu |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1507828/full |
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