Sequential 90Y Selective Internal Radiation Therapy (SIRT) and Stereotactic Body Radiation Therapy (SBRT) using 90Y PET-based Absorbed Dose Maps: Interim Analysis of a Phase 1 Study

Sequential 90Y Selective Internal Radiation Therapy (SIRT) and Stereotactic Body Radiation Therapy (SBRT) using 90Y PET-based Absorbed Dose Maps: Interim Analysis of a Phase 1 Study

Purpose: Selective internal radiation therapy (SIRT) can result in heterogeneous absorbed dose coverage. To address potential underdosing of lesions with SIRT, we designed a phase 1 clinical trial (NCT04518748) to add stereotactic body radiation therapy (SBRT) 6 weeks after 90Y SIRT. Methods and Mat...

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Main Authors: Daniel F. Polan, PhD, Justin K. Mikell, PhD, Kellen Fitzpatrick, MS, Joseph J. Gemmete, MD, Jared A. Christensen, MD, Hassan Anbari, MD, Molly Roseland, MD, Joseph R. Evans, MD, PhD, Daniel T. Chang, MD, Mamadou Sanogo, MD, Baljendra S. Kapoor, MD, Matthew J. Schipper, PhD, Yue Cao, PhD, Madhava P. Aryal, Theodore S. Lawrence, MD, PhD, Kyle C. Cuneo, MD, Yuni K. Dewaraja, PhD
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Advances in Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2452109425000314
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