Role of high-density lipoprotein cholesterol in health and diseases
Primary function of high-density lipoprotein cholesterol is to reverse transport the cholesterol from extrahepatic cell to liver for its metabolism and excretion. Studies have demonstrated the anti-inflammatory, anti-atherogenic, anti-oxidant, and anti-diabetic property of the high-density lipoprote...
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| Language: | English |
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SAGE Publishing
2021-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=2;spage=187;epage=193;aulast=Yadav |
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| _version_ | 1832569168779542528 |
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| author | Brijesh Yadav Narayan Prasad |
| author_facet | Brijesh Yadav Narayan Prasad |
| author_sort | Brijesh Yadav |
| collection | DOAJ |
| description | Primary function of high-density lipoprotein cholesterol is to reverse transport the cholesterol from extrahepatic cell to liver for its metabolism and excretion. Studies have demonstrated the anti-inflammatory, anti-atherogenic, anti-oxidant, and anti-diabetic property of the high-density lipoprotein cholesterol. Although the exact mechanism still remains unelucidated, high-density lipoprotein cholesterol is a complex of lipids and proteins carrying many associated cargo molecules such as enzymes, signaling molecules, miRNA, which imparts overall functionality of high-density lipoprotein cholesterol for its beneficial health effects. However, the protein and lipids components get transform by the enzymes associated with high-density lipoprotein cholesterol, hyperglycemia, oxidative stressor, and free radicals, leading to qualitative and quantitative alterations in high-density lipoprotein cholesterol (HDLc) and diminishes its beneficial effects. In this review, we have discussed the different property of high-density lipoprotein cholesterol, its function and factors influencing HDLc property in light of anti-inflammatory activity in rheumatoid arthritis and the role of cholesterol-lowering statin drug in enhancing the beneficial effect of high-density lipoprotein cholesterol in different cell types. |
| format | Article |
| id | doaj-art-0fc2030d98464bfeb64ae42cb8568387 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-0fc2030d98464bfeb64ae42cb85683872025-02-02T22:47:46ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012021-01-0116218719310.4103/injr.injr_240_20Role of high-density lipoprotein cholesterol in health and diseasesBrijesh YadavNarayan PrasadPrimary function of high-density lipoprotein cholesterol is to reverse transport the cholesterol from extrahepatic cell to liver for its metabolism and excretion. Studies have demonstrated the anti-inflammatory, anti-atherogenic, anti-oxidant, and anti-diabetic property of the high-density lipoprotein cholesterol. Although the exact mechanism still remains unelucidated, high-density lipoprotein cholesterol is a complex of lipids and proteins carrying many associated cargo molecules such as enzymes, signaling molecules, miRNA, which imparts overall functionality of high-density lipoprotein cholesterol for its beneficial health effects. However, the protein and lipids components get transform by the enzymes associated with high-density lipoprotein cholesterol, hyperglycemia, oxidative stressor, and free radicals, leading to qualitative and quantitative alterations in high-density lipoprotein cholesterol (HDLc) and diminishes its beneficial effects. In this review, we have discussed the different property of high-density lipoprotein cholesterol, its function and factors influencing HDLc property in light of anti-inflammatory activity in rheumatoid arthritis and the role of cholesterol-lowering statin drug in enhancing the beneficial effect of high-density lipoprotein cholesterol in different cell types.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=2;spage=187;epage=193;aulast=Yadavabca1apo-a1cholesterolhigh-density lipoprotein cholesteroltreg |
| spellingShingle | Brijesh Yadav Narayan Prasad Role of high-density lipoprotein cholesterol in health and diseases Indian Journal of Rheumatology abca1 apo-a1 cholesterol high-density lipoprotein cholesterol treg |
| title | Role of high-density lipoprotein cholesterol in health and diseases |
| title_full | Role of high-density lipoprotein cholesterol in health and diseases |
| title_fullStr | Role of high-density lipoprotein cholesterol in health and diseases |
| title_full_unstemmed | Role of high-density lipoprotein cholesterol in health and diseases |
| title_short | Role of high-density lipoprotein cholesterol in health and diseases |
| title_sort | role of high density lipoprotein cholesterol in health and diseases |
| topic | abca1 apo-a1 cholesterol high-density lipoprotein cholesterol treg |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=2;spage=187;epage=193;aulast=Yadav |
| work_keys_str_mv | AT brijeshyadav roleofhighdensitylipoproteincholesterolinhealthanddiseases AT narayanprasad roleofhighdensitylipoproteincholesterolinhealthanddiseases |