Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength.

Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength.

Chemical synaptic transmission at the neuromuscular junction (NMJ) is regulated by electrical activity of the motor circuit, but may also be affected by neuromodulation. Here, we assessed the role of neuropeptide signaling in the plasticity of NMJ function in Caenorhabditis elegans. We show that the...

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Bibliographic Details
Main Authors: Jiajie Shao, Jana F Liewald, Wagner Steuer Costa, Christiane Ruse, Jens Gruber, Mohammad S Djamshedzad, Wulf Gebhardt, Alexander Gottschalk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003171
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