Clinical features and treatment results in children with anaplastic large cell lymphoma
Anaplastic large cell lymphoma (ALCL) tends to have frequent relapse and good response to salvage chemotherapy. The frequency of ALCL among 1486 Non-Hodgkin's lymphoma (NHL) cases followed-up since 1972 was 1.5%, however, the percentage was 9.3% in cases diagnosed after 2000. Event-free...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2015-10-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1268 |
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| _version_ | 1849705880399904768 |
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| author | Erman Ataş M Tezer Kutluk Canan Akyüz Gülsev Kale Ali Varan Bilgehan Yalçın Burça Aydın Münevver Büyükpamukçu |
| author_facet | Erman Ataş M Tezer Kutluk Canan Akyüz Gülsev Kale Ali Varan Bilgehan Yalçın Burça Aydın Münevver Büyükpamukçu |
| author_sort | Erman Ataş |
| collection | DOAJ |
| description |
Anaplastic large cell lymphoma (ALCL) tends to have frequent relapse and good response to salvage chemotherapy. The frequency of ALCL among 1486 Non-Hodgkin's lymphoma (NHL) cases followed-up since 1972 was 1.5%, however, the percentage was 9.3% in cases diagnosed after 2000. Event-free survival (EFS) and overall survival (OS) rates for 23 children were 32.2% and 72.8% at 3 years, respectively. Disseminated diseases, no response to first line treatment, anaplastic lymphoma kinase (ALK) negativity were found as significant predictors on survival of ALCL. The proper diagnosis and early referral is essential in these children for a better survival rate. The children with ALK negative status should be monitored carefully because of the poor prognostic factors, and treated differently. The survival rates in this study are need of further improvement since the survival rates with current protocols are achievable at a level more than 80%. This is mainly related with late referral of those children with advanced disease.
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| format | Article |
| id | doaj-art-0fc0d9b4172d4a60940a979c38c7f6fe |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2015-10-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-0fc0d9b4172d4a60940a979c38c7f6fe2025-08-20T03:16:22ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212015-10-01575Clinical features and treatment results in children with anaplastic large cell lymphomaErman Ataş0M Tezer KutlukCanan AkyüzGülsev KaleAli VaranBilgehan YalçınBurça AydınMünevver BüyükpamukçuDivision of Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara Turkey. tezerkutluk@gmail.com. Anaplastic large cell lymphoma (ALCL) tends to have frequent relapse and good response to salvage chemotherapy. The frequency of ALCL among 1486 Non-Hodgkin's lymphoma (NHL) cases followed-up since 1972 was 1.5%, however, the percentage was 9.3% in cases diagnosed after 2000. Event-free survival (EFS) and overall survival (OS) rates for 23 children were 32.2% and 72.8% at 3 years, respectively. Disseminated diseases, no response to first line treatment, anaplastic lymphoma kinase (ALK) negativity were found as significant predictors on survival of ALCL. The proper diagnosis and early referral is essential in these children for a better survival rate. The children with ALK negative status should be monitored carefully because of the poor prognostic factors, and treated differently. The survival rates in this study are need of further improvement since the survival rates with current protocols are achievable at a level more than 80%. This is mainly related with late referral of those children with advanced disease. https://turkjpediatr.org/article/view/1268 |
| spellingShingle | Erman Ataş M Tezer Kutluk Canan Akyüz Gülsev Kale Ali Varan Bilgehan Yalçın Burça Aydın Münevver Büyükpamukçu Clinical features and treatment results in children with anaplastic large cell lymphoma The Turkish Journal of Pediatrics |
| title | Clinical features and treatment results in children with anaplastic large cell lymphoma |
| title_full | Clinical features and treatment results in children with anaplastic large cell lymphoma |
| title_fullStr | Clinical features and treatment results in children with anaplastic large cell lymphoma |
| title_full_unstemmed | Clinical features and treatment results in children with anaplastic large cell lymphoma |
| title_short | Clinical features and treatment results in children with anaplastic large cell lymphoma |
| title_sort | clinical features and treatment results in children with anaplastic large cell lymphoma |
| url | https://turkjpediatr.org/article/view/1268 |
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