Dopamine Drives Feedforward Inhibition to Orexin Feeding System, Mediating Weight Loss Induced by Morphine Addiction

Dopamine Drives Feedforward Inhibition to Orexin Feeding System, Mediating Weight Loss Induced by Morphine Addiction

Abstract Feeding behavior changes induced by opioid addiction significantly contribute to the worsening opioid crisis. Activation of the reward system has shown to provoke binge eating disorder in individuals with opioid use disorder, whereas prolonged opioid exposure leads to weight loss. Understan...

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Bibliographic Details
Main Authors: Huiming Li, Sa Wang, Dan Wang, Jiannan Li, Ge Song, Yongxin Guo, Lu Yin, Tingting Tong, Haopeng Zhang, Hailong Dong
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
body weight
dopamine
feedforward inhibition
feeding behaviors
morphine addiction
neural circuits
Online Access:https://doi.org/10.1002/advs.202411858
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