Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors
Objective. The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) on cardiovascular risk factors in patients with ankylosing spondylitis (AS). Material and Methods. We investigated the effect of WBC with subsequent kinesiotherapy on markers of inflammation, oxidative stress,...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/8592532 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551786419847168 |
|---|---|
| author | Agata Stanek Armand Cholewka Tomasz Wielkoszyński Ewa Romuk Aleksander Sieroń |
| author_facet | Agata Stanek Armand Cholewka Tomasz Wielkoszyński Ewa Romuk Aleksander Sieroń |
| author_sort | Agata Stanek |
| collection | DOAJ |
| description | Objective. The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) on cardiovascular risk factors in patients with ankylosing spondylitis (AS). Material and Methods. We investigated the effect of WBC with subsequent kinesiotherapy on markers of inflammation, oxidative stress, lipid profile, and atherosclerosis plaque in male AS patients (WBC group). To assess the disease activity, the BASDAI and BASFI were also calculated. The results from the WBC group were compared with results from the kinesiotherapy (KT) group. Results. The results showed that in the WBC group, the plasma hsCRP level decreased without change to the IL-6 level. The ICAM-1 level showed a decreasing tendency. The CER concentration, as well as the BASDAI and BASFI, decreased in both groups, but the index changes of disease activity were higher in the WBC than KT patients. Additionally, in the WBC group, we observed a decrease in oxidative stress markers, changes in the activity of some antioxidant enzymes and nonenzymatic antioxidant parameters. In both groups, the total cholesterol and LDL cholesterol, triglycerides, sCD40L, PAPP-A, and PLGF levels decreased, but the parameter changes were higher in the WBC group. Conclusion. WBC appears to be a useful method of atherosclerosis prevention in AS patients. |
| format | Article |
| id | doaj-art-0fb8f5647d5c469ab81a7e4685eb2f4a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0fb8f5647d5c469ab81a7e4685eb2f4a2025-02-03T06:00:22ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/85925328592532Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk FactorsAgata Stanek0Armand Cholewka1Tomasz Wielkoszyński2Ewa Romuk3Aleksander Sieroń4School of Medicine with the Division of Dentistry in Zabrze, Department of Internal Medicine, Angiology and Physical Medicine, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, PolandDepartment of Medical Physics, Chełkowski Institute of Physics, University of Silesia, 4 Uniwersytecka St., 40-007 Katowice, PolandSchool of Medicine with the Division of Dentistry in Zabrze, Department of Biochemistry, Medical University of Silesia, Jordana 19 St., 41-808 Zabrze, PolandSchool of Medicine with the Division of Dentistry in Zabrze, Department of Biochemistry, Medical University of Silesia, Jordana 19 St., 41-808 Zabrze, PolandSchool of Medicine with the Division of Dentistry in Zabrze, Department of Internal Medicine, Angiology and Physical Medicine, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, PolandObjective. The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) on cardiovascular risk factors in patients with ankylosing spondylitis (AS). Material and Methods. We investigated the effect of WBC with subsequent kinesiotherapy on markers of inflammation, oxidative stress, lipid profile, and atherosclerosis plaque in male AS patients (WBC group). To assess the disease activity, the BASDAI and BASFI were also calculated. The results from the WBC group were compared with results from the kinesiotherapy (KT) group. Results. The results showed that in the WBC group, the plasma hsCRP level decreased without change to the IL-6 level. The ICAM-1 level showed a decreasing tendency. The CER concentration, as well as the BASDAI and BASFI, decreased in both groups, but the index changes of disease activity were higher in the WBC than KT patients. Additionally, in the WBC group, we observed a decrease in oxidative stress markers, changes in the activity of some antioxidant enzymes and nonenzymatic antioxidant parameters. In both groups, the total cholesterol and LDL cholesterol, triglycerides, sCD40L, PAPP-A, and PLGF levels decreased, but the parameter changes were higher in the WBC group. Conclusion. WBC appears to be a useful method of atherosclerosis prevention in AS patients.http://dx.doi.org/10.1155/2018/8592532 |
| spellingShingle | Agata Stanek Armand Cholewka Tomasz Wielkoszyński Ewa Romuk Aleksander Sieroń Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors Mediators of Inflammation |
| title | Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors |
| title_full | Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors |
| title_fullStr | Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors |
| title_full_unstemmed | Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors |
| title_short | Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors |
| title_sort | whole body cryotherapy decreases the levels of inflammatory oxidative stress and atherosclerosis plaque markers in male patients with active phase ankylosing spondylitis in the absence of classical cardiovascular risk factors |
| url | http://dx.doi.org/10.1155/2018/8592532 |
| work_keys_str_mv | AT agatastanek wholebodycryotherapydecreasesthelevelsofinflammatoryoxidativestressandatherosclerosisplaquemarkersinmalepatientswithactivephaseankylosingspondylitisintheabsenceofclassicalcardiovascularriskfactors AT armandcholewka wholebodycryotherapydecreasesthelevelsofinflammatoryoxidativestressandatherosclerosisplaquemarkersinmalepatientswithactivephaseankylosingspondylitisintheabsenceofclassicalcardiovascularriskfactors AT tomaszwielkoszynski wholebodycryotherapydecreasesthelevelsofinflammatoryoxidativestressandatherosclerosisplaquemarkersinmalepatientswithactivephaseankylosingspondylitisintheabsenceofclassicalcardiovascularriskfactors AT ewaromuk wholebodycryotherapydecreasesthelevelsofinflammatoryoxidativestressandatherosclerosisplaquemarkersinmalepatientswithactivephaseankylosingspondylitisintheabsenceofclassicalcardiovascularriskfactors AT aleksandersieron wholebodycryotherapydecreasesthelevelsofinflammatoryoxidativestressandatherosclerosisplaquemarkersinmalepatientswithactivephaseankylosingspondylitisintheabsenceofclassicalcardiovascularriskfactors |