Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis

Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis

Abstract Jaundice, the clinical hallmark of infection‐associated liver dysfunction, reflects altered membrane organization of the canalicular pole of hepatocytes and portends poor outcomes. Mice lacking phosphoinositide 3‐kinase‐γ (PI3Kγ) are protected against membrane disintegration and hepatic exc...

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Main Authors: Adrian T Press, Petra Babic, Bianca Hoffmann, Tina Müller, Wanling Foo, Walter Hauswald, Jovana Benecke, Martina Beretta, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Sina M Coldewey, Markus H Gräler, Reinhard Bauer, Falk Gonnert, Nikolaus Gaßler, Reinhard Wetzker, Marc Thilo Figge, Ulrich S Schubert, Michael Bauer
Format: Article
Language:English
Published: Springer Nature 2021-09-01
Series:EMBO Molecular Medicine
Subjects:
cholestasis
drug delivery
liver failure
PI3K
sepsis
Online Access:https://doi.org/10.15252/emmm.202114436
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