The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio
Objective. To investigate the expression of miR-192 and its significance in diabetic nephropathy (DN) patients. Methods. 464 patients with type 2 diabetes mellitus (T2DM) were divided into normal albuminuria group (NA, n=157), microalbuminuria group (MA, n=159), and large amount of albuminuria group...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6789402 |
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| author | Xiaoyu Ma Canlu Lu Chuan Lv Can Wu Qiuyue Wang |
| author_facet | Xiaoyu Ma Canlu Lu Chuan Lv Can Wu Qiuyue Wang |
| author_sort | Xiaoyu Ma |
| collection | DOAJ |
| description | Objective. To investigate the expression of miR-192 and its significance in diabetic nephropathy (DN) patients. Methods. 464 patients with type 2 diabetes mellitus (T2DM) were divided into normal albuminuria group (NA, n=157), microalbuminuria group (MA, n=159), and large amount of albuminuria group (LA, n=148). 127 healthy persons were selected as the control group (NC, n=127). The serum miR-192 levels were detected by Real-Time PCR and transforming growth factor-β1 (TGF-β1) and fibronectin (FN) were detected by enzyme-linked immunosorbent assay. The relationships among these parameters were analyzed by Pearson correlation analysis and multiple linear regression analysis. Results. The miR-192 in the LA group was significantly lower than other groups, which was lower in the MA group than in the NA group (P<0.01). The TGF-β1 and FN in the LA group were significantly higher than other groups, which were higher in the MA group than in the NA group (P<0.01). The expression of miR-192 was negatively correlated with TGF-β1, FN, and Ln (UACR) and miR-192, TGF-β1, and FN were independent relevant factors affecting Ln (UACR) in T2DM (P<0.01). Conclusions. These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN. |
| format | Article |
| id | doaj-art-0fab4719d8da4908bcb627c89dc18942 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-0fab4719d8da4908bcb627c89dc189422025-02-03T05:45:10ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/67894026789402The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine RatioXiaoyu Ma0Canlu Lu1Chuan Lv2Can Wu3Qiuyue Wang4Geriatrics Department, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaEndocrine Department, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaEndocrine Department, The People Hospital of Liaoning Province, Shenyang, Liaoning, ChinaEndocrine Department, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaEndocrine Department, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaObjective. To investigate the expression of miR-192 and its significance in diabetic nephropathy (DN) patients. Methods. 464 patients with type 2 diabetes mellitus (T2DM) were divided into normal albuminuria group (NA, n=157), microalbuminuria group (MA, n=159), and large amount of albuminuria group (LA, n=148). 127 healthy persons were selected as the control group (NC, n=127). The serum miR-192 levels were detected by Real-Time PCR and transforming growth factor-β1 (TGF-β1) and fibronectin (FN) were detected by enzyme-linked immunosorbent assay. The relationships among these parameters were analyzed by Pearson correlation analysis and multiple linear regression analysis. Results. The miR-192 in the LA group was significantly lower than other groups, which was lower in the MA group than in the NA group (P<0.01). The TGF-β1 and FN in the LA group were significantly higher than other groups, which were higher in the MA group than in the NA group (P<0.01). The expression of miR-192 was negatively correlated with TGF-β1, FN, and Ln (UACR) and miR-192, TGF-β1, and FN were independent relevant factors affecting Ln (UACR) in T2DM (P<0.01). Conclusions. These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN.http://dx.doi.org/10.1155/2016/6789402 |
| spellingShingle | Xiaoyu Ma Canlu Lu Chuan Lv Can Wu Qiuyue Wang The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio Journal of Diabetes Research |
| title | The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio |
| title_full | The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio |
| title_fullStr | The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio |
| title_full_unstemmed | The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio |
| title_short | The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio |
| title_sort | expression of mir 192 and its significance in diabetic nephropathy patients with different urine albumin creatinine ratio |
| url | http://dx.doi.org/10.1155/2016/6789402 |
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