Association of Serum Glutathione with Bone Mineral Density in Females with Osteopenia and Osteoporosis
Background: Low bone mineral density is a hallmark of osteoporosis. Changes in the levels of reactive oxygen species and the body’s natural antioxidant system lead to oxidative stress, which, by modulating the activity of osteoblasts and osteoclasts, can lead to bone resorption and, ultimately, fr...
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| Format: | Article |
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Liaquat National Hospital and Medical College
2025-04-01
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| Series: | Liaquat National Journal of Primary Care |
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| Online Access: | https://journals.lnh.edu.pk/lnjpc/pdf/3b03b9bc-bbed-49ee-942d-4e19446d9636.pdf |
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| author | Mannal Saleem Sampana Fatima Iqra Anwar Rafia Yasmin Khan Rahat Bano Siddiqui Rabia Rauf Muhammad Abrar |
| author_facet | Mannal Saleem Sampana Fatima Iqra Anwar Rafia Yasmin Khan Rahat Bano Siddiqui Rabia Rauf Muhammad Abrar |
| author_sort | Mannal Saleem |
| collection | DOAJ |
| description | Background: Low bone mineral density is a hallmark of osteoporosis. Changes in the levels of reactive oxygen species and the
body’s natural antioxidant system lead to oxidative stress, which, by modulating the activity of osteoblasts and osteoclasts, can lead
to bone resorption and, ultimately, fracture and associated morbidities.
Objective: To find the association of serum glutathione with bone mineral density in females with osteopenia and osteoporosis in
Lahore, Pakistan.
Methods: A cross-sectional study was conducted in Shalamar Hospital, Lahore, from September 2022 to August 2023. After a
written informed consent form, 100 females above 42 years of age were selected as study participants. Demographic characteristics,
including height, weight, and blood pressure, were recorded. The bone mineral density of the left calcaneum was determined with
Sonost 3000, and 0.5ml of intravenous blood sample was taken.
Results: Average age of study participants was 52±8 years with the majority of females between 50-58 years of age. This study
found a statistically significant association of serum glutathione with bone mineral density (p<0.05) and serum glutathione levels
greater than 4.2ng/dl possess a 41.4% protective effect in the development of osteoporosis in the adjusted model.
Conclusion: The current study’s results indicate the need for glutathione, a non-enzymatic antioxidant, to prevent or at least halt
osteoporosis. The present study may also suggest the potential role of glutathione as a biochemical marker for the diagnosis of
oxidative stress in bone. |
| format | Article |
| id | doaj-art-0fa7cc848d5b42d8bcdb2c59f9343af9 |
| institution | DOAJ |
| issn | 2707-3521 2708-9134 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Liaquat National Hospital and Medical College |
| record_format | Article |
| series | Liaquat National Journal of Primary Care |
| spelling | doaj-art-0fa7cc848d5b42d8bcdb2c59f9343af92025-08-20T03:06:47ZengLiaquat National Hospital and Medical CollegeLiaquat National Journal of Primary Care2707-35212708-91342025-04-017212512910.37184/lnjpc.2707-3521.7.41Association of Serum Glutathione with Bone Mineral Density in Females with Osteopenia and OsteoporosisMannal Saleem0Sampana Fatima1Iqra Anwar2Rafia Yasmin Khan3Rahat Bano Siddiqui4Rabia Rauf5Muhammad Abrar6Medicine Department, Govt. Shahbaz Sharif DHQ Hospital, Multan, PakistanPhysiology Department, Shalamar Medical and Dental College, Lahore, PakistanBiochemistry Department, Watim Medical College, Rawalpindi, PakistanEye Department, Bahawal Victoria Hospital, Bahawalpur, PakistanAnatomy Department, Fazaia Ruth Pfau Medical College, Karachi, PakistanAnatomy Department, Niazi Medical and Dental College, Sargodha, PakistanEngineering Department, NUST College of EME, Rawalpindi, PakistanBackground: Low bone mineral density is a hallmark of osteoporosis. Changes in the levels of reactive oxygen species and the body’s natural antioxidant system lead to oxidative stress, which, by modulating the activity of osteoblasts and osteoclasts, can lead to bone resorption and, ultimately, fracture and associated morbidities. Objective: To find the association of serum glutathione with bone mineral density in females with osteopenia and osteoporosis in Lahore, Pakistan. Methods: A cross-sectional study was conducted in Shalamar Hospital, Lahore, from September 2022 to August 2023. After a written informed consent form, 100 females above 42 years of age were selected as study participants. Demographic characteristics, including height, weight, and blood pressure, were recorded. The bone mineral density of the left calcaneum was determined with Sonost 3000, and 0.5ml of intravenous blood sample was taken. Results: Average age of study participants was 52±8 years with the majority of females between 50-58 years of age. This study found a statistically significant association of serum glutathione with bone mineral density (p<0.05) and serum glutathione levels greater than 4.2ng/dl possess a 41.4% protective effect in the development of osteoporosis in the adjusted model. Conclusion: The current study’s results indicate the need for glutathione, a non-enzymatic antioxidant, to prevent or at least halt osteoporosis. The present study may also suggest the potential role of glutathione as a biochemical marker for the diagnosis of oxidative stress in bone.https://journals.lnh.edu.pk/lnjpc/pdf/3b03b9bc-bbed-49ee-942d-4e19446d9636.pdfoxidative stressbone mineral densityosteoporosisantioxidantglutathione. |
| spellingShingle | Mannal Saleem Sampana Fatima Iqra Anwar Rafia Yasmin Khan Rahat Bano Siddiqui Rabia Rauf Muhammad Abrar Association of Serum Glutathione with Bone Mineral Density in Females with Osteopenia and Osteoporosis Liaquat National Journal of Primary Care oxidative stress bone mineral density osteoporosis antioxidant glutathione. |
| title | Association of Serum Glutathione with Bone Mineral Density in Females with Osteopenia and Osteoporosis |
| title_full | Association of Serum Glutathione with Bone Mineral Density in Females with Osteopenia and Osteoporosis |
| title_fullStr | Association of Serum Glutathione with Bone Mineral Density in Females with Osteopenia and Osteoporosis |
| title_full_unstemmed | Association of Serum Glutathione with Bone Mineral Density in Females with Osteopenia and Osteoporosis |
| title_short | Association of Serum Glutathione with Bone Mineral Density in Females with Osteopenia and Osteoporosis |
| title_sort | association of serum glutathione with bone mineral density in females with osteopenia and osteoporosis |
| topic | oxidative stress bone mineral density osteoporosis antioxidant glutathione. |
| url | https://journals.lnh.edu.pk/lnjpc/pdf/3b03b9bc-bbed-49ee-942d-4e19446d9636.pdf |
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