Rs145204276 and rs4759314 affect the prognosis of prostate cancer by modulating the GAS5/miR-1284/HMGB1 and HOTAIR/miR-22/HMGB1 signalling pathways
Non-coding RNAs play an important role in the pathogenesis of prostate cancer (PC). This study aims to characterize the role of GAS5 rs145204276 and HOTAIR rs4759314 polymorphisms in the pathogenesis of PC. Both INS allele of GAS5 rs145204276 and A allele of HOTAIR rs4759314 were identified to incre...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1709859 |
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| author | Zhi-Hai Deng Gan-Shen Yu Bin Pan Zhen-Hua Feng Qiang Huang Jian-Zhong Deng Bo Chen Shi-Kun Yang |
| author_facet | Zhi-Hai Deng Gan-Shen Yu Bin Pan Zhen-Hua Feng Qiang Huang Jian-Zhong Deng Bo Chen Shi-Kun Yang |
| author_sort | Zhi-Hai Deng |
| collection | DOAJ |
| description | Non-coding RNAs play an important role in the pathogenesis of prostate cancer (PC). This study aims to characterize the role of GAS5 rs145204276 and HOTAIR rs4759314 polymorphisms in the pathogenesis of PC. Both INS allele of GAS5 rs145204276 and A allele of HOTAIR rs4759314 were identified to increase the survival of PC patients. And patients carrying DEL/DEL + AG genotypes tend to present higher levels of HMGB1, GAS5, HOTAIR and lower levels of miR-1284 and miR-22. In addition, the transcription activity of GAS5 promoter was increased by the deletion allele of rs145204276 polymorphism, while the G allele of rs4759314 polymorphism increased the transcription activity of HOTAIR promoter. GAS5 and HOTAIR could bind to miR-1284 and miR-22, respectively, while miR-1284 and miR-22 could bind to the 3′UTR of HMGB1. Compared with the control group, the expressions of miR-1284 or miR-22 were decreased with the presence of GAS5 or HOTAIR, and the expression of HMGB1 was the highest in the GAS5 + HOTAIR group. In summary, the findings of this study demonstrated that both GAS5 rs145204276 and HOTAIR rs4759314 polymorphisms could affect the prognosis of PC by modulating the expression of HMGB1 via modulating the GAS5/miR-1284/HMGB1 and HOTAIR/miR-22/HMGB1 signalling pathways. |
| format | Article |
| id | doaj-art-0fa4c989a7fc451fbb9b9ec1f25f3678 |
| institution | Kabale University |
| issn | 2169-1401 2169-141X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj-art-0fa4c989a7fc451fbb9b9ec1f25f36782025-08-20T03:41:51ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2020-01-0148143544210.1080/21691401.2019.1709859Rs145204276 and rs4759314 affect the prognosis of prostate cancer by modulating the GAS5/miR-1284/HMGB1 and HOTAIR/miR-22/HMGB1 signalling pathwaysZhi-Hai Deng0Gan-Shen Yu1Bin Pan2Zhen-Hua Feng3Qiang Huang4Jian-Zhong Deng5Bo Chen6Shi-Kun Yang7Department of Urology, Gaozhou People's Hospital, Gaozhou, Guangdong, ChinaDepartment of Urology, Maoming People's Hospital, Maoming, Guangdong, ChinaDepartment of Urology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Urology, Gaozhou People's Hospital, Gaozhou, Guangdong, ChinaDepartment of Urology, Gaozhou People's Hospital, Gaozhou, Guangdong, ChinaDepartment of Urology, Gaozhou People's Hospital, Gaozhou, Guangdong, ChinaDepartment of Urology, Gaozhou People's Hospital, Gaozhou, Guangdong, ChinaDepartment of Urology, Yanghe People's hospital, Suqian, Jiangsu, ChinaNon-coding RNAs play an important role in the pathogenesis of prostate cancer (PC). This study aims to characterize the role of GAS5 rs145204276 and HOTAIR rs4759314 polymorphisms in the pathogenesis of PC. Both INS allele of GAS5 rs145204276 and A allele of HOTAIR rs4759314 were identified to increase the survival of PC patients. And patients carrying DEL/DEL + AG genotypes tend to present higher levels of HMGB1, GAS5, HOTAIR and lower levels of miR-1284 and miR-22. In addition, the transcription activity of GAS5 promoter was increased by the deletion allele of rs145204276 polymorphism, while the G allele of rs4759314 polymorphism increased the transcription activity of HOTAIR promoter. GAS5 and HOTAIR could bind to miR-1284 and miR-22, respectively, while miR-1284 and miR-22 could bind to the 3′UTR of HMGB1. Compared with the control group, the expressions of miR-1284 or miR-22 were decreased with the presence of GAS5 or HOTAIR, and the expression of HMGB1 was the highest in the GAS5 + HOTAIR group. In summary, the findings of this study demonstrated that both GAS5 rs145204276 and HOTAIR rs4759314 polymorphisms could affect the prognosis of PC by modulating the expression of HMGB1 via modulating the GAS5/miR-1284/HMGB1 and HOTAIR/miR-22/HMGB1 signalling pathways.https://www.tandfonline.com/doi/10.1080/21691401.2019.1709859Prostate cancerrs145204276rs4759314miR-1284miR-22GAS5 |
| spellingShingle | Zhi-Hai Deng Gan-Shen Yu Bin Pan Zhen-Hua Feng Qiang Huang Jian-Zhong Deng Bo Chen Shi-Kun Yang Rs145204276 and rs4759314 affect the prognosis of prostate cancer by modulating the GAS5/miR-1284/HMGB1 and HOTAIR/miR-22/HMGB1 signalling pathways Artificial Cells, Nanomedicine, and Biotechnology Prostate cancer rs145204276 rs4759314 miR-1284 miR-22 GAS5 |
| title | Rs145204276 and rs4759314 affect the prognosis of prostate cancer by modulating the GAS5/miR-1284/HMGB1 and HOTAIR/miR-22/HMGB1 signalling pathways |
| title_full | Rs145204276 and rs4759314 affect the prognosis of prostate cancer by modulating the GAS5/miR-1284/HMGB1 and HOTAIR/miR-22/HMGB1 signalling pathways |
| title_fullStr | Rs145204276 and rs4759314 affect the prognosis of prostate cancer by modulating the GAS5/miR-1284/HMGB1 and HOTAIR/miR-22/HMGB1 signalling pathways |
| title_full_unstemmed | Rs145204276 and rs4759314 affect the prognosis of prostate cancer by modulating the GAS5/miR-1284/HMGB1 and HOTAIR/miR-22/HMGB1 signalling pathways |
| title_short | Rs145204276 and rs4759314 affect the prognosis of prostate cancer by modulating the GAS5/miR-1284/HMGB1 and HOTAIR/miR-22/HMGB1 signalling pathways |
| title_sort | rs145204276 and rs4759314 affect the prognosis of prostate cancer by modulating the gas5 mir 1284 hmgb1 and hotair mir 22 hmgb1 signalling pathways |
| topic | Prostate cancer rs145204276 rs4759314 miR-1284 miR-22 GAS5 |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1709859 |
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