Lymphocyte Subpopulations in Pulmonary Tuberculosis Patients
Protection against Mycobacterium tuberculosis is based on cell-mediated immunity, most importantly involving CD4+ and CD8+ T-cell subsets. The aim of this study was to evaluate CD4+ and CD8+ T-cell profiles and CD19+ and CD3-CD(16+56)+ populations in patients with pulmonary tuberculosis. CD4+ and CD...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/89070 |
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| author | Figen Deveci H. Handan Akbulut Ilhami Celik M. Hamdi Muz Fulya İlhan |
| author_facet | Figen Deveci H. Handan Akbulut Ilhami Celik M. Hamdi Muz Fulya İlhan |
| author_sort | Figen Deveci |
| collection | DOAJ |
| description | Protection against Mycobacterium
tuberculosis is based on cell-mediated immunity, most importantly
involving CD4+ and CD8+ T-cell subsets. The aim of this study was to evaluate CD4+
and CD8+ T-cell profiles and CD19+ and CD3-CD(16+56)+ populations in patients with pulmonary
tuberculosis. CD4+ and CD8+ T cells, B-lymphocytes, and natural killer (NK) cells were evaluated in 75
active (APTB) and 25 inactive (IPTB) pulmonary tuberculosis cases
and 20 healthy subjects (HCs). The results were compared at
different stages of antituberculosis treatment in the APTB
patients and also according to X-ray findings in the newly
diagnosed APTB patients. The percentages of
CD4+ T cells were significantly lower (P<.01) and those of
CD3-CD(16+56)+ cells were significantly higher (P<.01)
in APTB patients than in HCs. CD8+ T cells were significantly
decreased (P<.05), and CD3-CD(16+56)+ cells were
significantly increased (P<.01), in IPTB patients compared to
HCs. The percentages of CD4+, CD8+, CD3-CD19+, and CD3-CD(16+56)+ cells showed no differences at
different times of the antituberculosis regimen, and different
stages of newly diagnosed APTB patients. APTB
patients have a reduced percentage of circulating CD4+ T cells and an increased percentage of NK cells compared with
healthy individuals. These cells could play important roles in the
immune response to M tuberculosis infection. |
| format | Article |
| id | doaj-art-0fa29504e4e54bb6b9b239c1497e7f11 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0fa29504e4e54bb6b9b239c1497e7f112025-02-03T07:23:52ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/8907089070Lymphocyte Subpopulations in Pulmonary Tuberculosis PatientsFigen Deveci0H. Handan Akbulut1Ilhami Celik2M. Hamdi Muz3Fulya İlhan4Department of Chest Diseases, Faculty of Medicine, Firat University, Elazig 23119, TurkeyDepartment of Immunology, Faculty of Medicine, Firat University, Elazig 23119, TurkeyDepartment of Clinical Microbiology and Infectious Diseases, Faculty of Medicine, Firat University, Elazig 23119, TurkeyDepartment of Chest Diseases, Faculty of Medicine, Firat University, Elazig 23119, TurkeyDepartment of Immunology, Faculty of Medicine, Firat University, Elazig 23119, TurkeyProtection against Mycobacterium tuberculosis is based on cell-mediated immunity, most importantly involving CD4+ and CD8+ T-cell subsets. The aim of this study was to evaluate CD4+ and CD8+ T-cell profiles and CD19+ and CD3-CD(16+56)+ populations in patients with pulmonary tuberculosis. CD4+ and CD8+ T cells, B-lymphocytes, and natural killer (NK) cells were evaluated in 75 active (APTB) and 25 inactive (IPTB) pulmonary tuberculosis cases and 20 healthy subjects (HCs). The results were compared at different stages of antituberculosis treatment in the APTB patients and also according to X-ray findings in the newly diagnosed APTB patients. The percentages of CD4+ T cells were significantly lower (P<.01) and those of CD3-CD(16+56)+ cells were significantly higher (P<.01) in APTB patients than in HCs. CD8+ T cells were significantly decreased (P<.05), and CD3-CD(16+56)+ cells were significantly increased (P<.01), in IPTB patients compared to HCs. The percentages of CD4+, CD8+, CD3-CD19+, and CD3-CD(16+56)+ cells showed no differences at different times of the antituberculosis regimen, and different stages of newly diagnosed APTB patients. APTB patients have a reduced percentage of circulating CD4+ T cells and an increased percentage of NK cells compared with healthy individuals. These cells could play important roles in the immune response to M tuberculosis infection.http://dx.doi.org/10.1155/MI/2006/89070 |
| spellingShingle | Figen Deveci H. Handan Akbulut Ilhami Celik M. Hamdi Muz Fulya İlhan Lymphocyte Subpopulations in Pulmonary Tuberculosis Patients Mediators of Inflammation |
| title | Lymphocyte Subpopulations in Pulmonary Tuberculosis Patients |
| title_full | Lymphocyte Subpopulations in Pulmonary Tuberculosis Patients |
| title_fullStr | Lymphocyte Subpopulations in Pulmonary Tuberculosis Patients |
| title_full_unstemmed | Lymphocyte Subpopulations in Pulmonary Tuberculosis Patients |
| title_short | Lymphocyte Subpopulations in Pulmonary Tuberculosis Patients |
| title_sort | lymphocyte subpopulations in pulmonary tuberculosis patients |
| url | http://dx.doi.org/10.1155/MI/2006/89070 |
| work_keys_str_mv | AT figendeveci lymphocytesubpopulationsinpulmonarytuberculosispatients AT hhandanakbulut lymphocytesubpopulationsinpulmonarytuberculosispatients AT ilhamicelik lymphocytesubpopulationsinpulmonarytuberculosispatients AT mhamdimuz lymphocytesubpopulationsinpulmonarytuberculosispatients AT fulyailhan lymphocytesubpopulationsinpulmonarytuberculosispatients |