Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases
A 41-year-old female presented to the hospital with sore throat and shortness of breath. She was hypoxic with an oxygen saturation of 87% in room air. Physical examination revealed swollen uvula with exudates. She had been started on topiramate for treatment of migraine few months ago. The dose of t...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/5846398 |
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| author | Saroj Lohani Niranjan Tachamo Salik Nazir Anthony Donato |
| author_facet | Saroj Lohani Niranjan Tachamo Salik Nazir Anthony Donato |
| author_sort | Saroj Lohani |
| collection | DOAJ |
| description | A 41-year-old female presented to the hospital with sore throat and shortness of breath. She was hypoxic with an oxygen saturation of 87% in room air. Physical examination revealed swollen uvula with exudates. She had been started on topiramate for treatment of migraine few months ago. The dose of topiramate was increased to 100 mg twice daily 2 weeks ago. Complete blood count revealed an absolute neutrophil count (ANC) of 8 c/mm3. She was intubated and started on broad-spectrum antibiotics. She was transferred to our hospital on the fifth day of hospitalization. On arrival, her absolute neutrophil count was 10 c/mm3. Her agranulocytosis was attributed to topiramate after ruling out other possible causes. ANC improved after topiramate was stopped. ANC increased to 1000 after 5 days of stopping topiramate. We also reviewed published cases of topiramate-associated agranulocytosis. Agranulocytosis is a rare side effect of topiramate, and only 3 case reports have been published so far. In all cases, agranulocytosis developed after months of topiramate therapy and when dose was increased to 200 mg daily suggesting a dose-dependent effect. Next steps would be further research on the pathogenesis of agranulocytosis associated with topiramate and creation of registry for data synthesis. |
| format | Article |
| id | doaj-art-0fa20b47b8be4c72934f07952c43c6e7 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-0fa20b47b8be4c72934f07952c43c6e72025-02-03T06:07:12ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/58463985846398Agranulocytosis Associated with Topiramate: A Case Report and Review of Published CasesSaroj Lohani0Niranjan Tachamo1Salik Nazir2Anthony Donato3Internal Medicine Residency, Reading Hospital, West Reading, PA, USAInternal Medicine Residency, Reading Hospital, West Reading, PA, USAInternal Medicine Residency, Reading Hospital, West Reading, PA, USASidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USAA 41-year-old female presented to the hospital with sore throat and shortness of breath. She was hypoxic with an oxygen saturation of 87% in room air. Physical examination revealed swollen uvula with exudates. She had been started on topiramate for treatment of migraine few months ago. The dose of topiramate was increased to 100 mg twice daily 2 weeks ago. Complete blood count revealed an absolute neutrophil count (ANC) of 8 c/mm3. She was intubated and started on broad-spectrum antibiotics. She was transferred to our hospital on the fifth day of hospitalization. On arrival, her absolute neutrophil count was 10 c/mm3. Her agranulocytosis was attributed to topiramate after ruling out other possible causes. ANC improved after topiramate was stopped. ANC increased to 1000 after 5 days of stopping topiramate. We also reviewed published cases of topiramate-associated agranulocytosis. Agranulocytosis is a rare side effect of topiramate, and only 3 case reports have been published so far. In all cases, agranulocytosis developed after months of topiramate therapy and when dose was increased to 200 mg daily suggesting a dose-dependent effect. Next steps would be further research on the pathogenesis of agranulocytosis associated with topiramate and creation of registry for data synthesis.http://dx.doi.org/10.1155/2018/5846398 |
| spellingShingle | Saroj Lohani Niranjan Tachamo Salik Nazir Anthony Donato Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases Case Reports in Hematology |
| title | Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases |
| title_full | Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases |
| title_fullStr | Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases |
| title_full_unstemmed | Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases |
| title_short | Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases |
| title_sort | agranulocytosis associated with topiramate a case report and review of published cases |
| url | http://dx.doi.org/10.1155/2018/5846398 |
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