BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireview
Oral squamous cell carcinoma (OSCC), a subset of head and neck cancers, primarily originates in the epithelial tissues of the oral cavity. Despite advancements in treatment, the mortality rate for OSCC remains around 50%, underscoring the urgent need for improved prognostic markers. This review expl...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1528822/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849338460177956864 |
|---|---|
| author | Dominika Gedeonová Dominika Gedeonová Claretta Bianchi Claretta Bianchi Jan Štembírek Jan Štembírek Jan Štembírek Matouš Hrdinka Matouš Hrdinka Zuzana Chyra Zuzana Chyra Marcela Buchtová Marcela Buchtová Pavel Hurník Pavel Hurník Tomáš Blažek Jana Režnarová Jana Režnarová |
| author_facet | Dominika Gedeonová Dominika Gedeonová Claretta Bianchi Claretta Bianchi Jan Štembírek Jan Štembírek Jan Štembírek Matouš Hrdinka Matouš Hrdinka Zuzana Chyra Zuzana Chyra Marcela Buchtová Marcela Buchtová Pavel Hurník Pavel Hurník Tomáš Blažek Jana Režnarová Jana Režnarová |
| author_sort | Dominika Gedeonová |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC), a subset of head and neck cancers, primarily originates in the epithelial tissues of the oral cavity. Despite advancements in treatment, the mortality rate for OSCC remains around 50%, underscoring the urgent need for improved prognostic markers. This review explores the role of the BRCA1 and BRCA2 genes—traditionally associated with breast and ovarian cancers—in the context of OSCC. We discuss the molecular pathways involving BRCA genes, their potential as diagnostics and prognostic biomarkers, and their implications for personalized treatment strategies, including addressing chemotherapy resistance. Furthermore, this review emphasizes the significance of genome stability in cancer progression and examines both current and emerging methodologies for detecting BRCA mutations in OSCC patients. Despite limited prevalence of BRCA mutations in OSCC compared to other cancers, their role in DNA repair and therapeutic response underscores their potential as clinical biomarkers. However, standardized, multicenter studies are still needed to validate their utility in OSCC management. A better understanding of the role of BRCA genes in OSCC could pave the way for more effective therapeutic approaches and improved patient outcomes. |
| format | Article |
| id | doaj-art-0fa1d85d46e2433aa4126492f40a2488 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-0fa1d85d46e2433aa4126492f40a24882025-08-20T03:44:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-03-011510.3389/fonc.2025.15288221528822BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireviewDominika Gedeonová0Dominika Gedeonová1Claretta Bianchi2Claretta Bianchi3Jan Štembírek4Jan Štembírek5Jan Štembírek6Matouš Hrdinka7Matouš Hrdinka8Zuzana Chyra9Zuzana Chyra10Marcela Buchtová11Marcela Buchtová12Pavel Hurník13Pavel Hurník14Tomáš Blažek15Jana Režnarová16Jana Režnarová17Department of Oral and Maxillofacial Surgery, University Hospital Ostrava, Ostrava, CzechiaDepartment of Craniofacial Surgery, Faculty of Medicine, University of Ostrava, Ostrava, CzechiaDepartment of Oral and Maxillofacial Surgery, University Hospital Ostrava, Ostrava, CzechiaHealth Research Centre, Faculty of Medicine, University of Ostrava, Ostrava, CzechiaDepartment of Oral and Maxillofacial Surgery, University Hospital Ostrava, Ostrava, CzechiaDepartment of Craniofacial Surgery, Faculty of Medicine, University of Ostrava, Ostrava, CzechiaInstitute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, CzechiaDepartment of Oral and Maxillofacial Surgery, University Hospital Ostrava, Ostrava, CzechiaHealth Research Centre, Faculty of Medicine, University of Ostrava, Ostrava, CzechiaDepartment of Hematooncology, University Hospital Ostrava, Ostrava, CzechiaDepartment of Hematology, Faculty of Medicine, University of Ostrava, Ostrava, CzechiaInstitute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, CzechiaDepartment of Experimental Biology, Faculty of Science, Masaryk University, Brno, CzechiaInstitute of Molecular and Clinical Pathology and Medical Genetics, University Hospital Ostrava, Ostrava, CzechiaInstitute of Molecular and Clinical Pathology and Medical Genetics, Faculty of Medicine, University of Ostrava, Ostrava, Czechia0Clinic of Oncology, University Hospital Ostrava, Ostrava, CzechiaDepartment of Oral and Maxillofacial Surgery, University Hospital Ostrava, Ostrava, CzechiaHealth Research Centre, Faculty of Medicine, University of Ostrava, Ostrava, CzechiaOral squamous cell carcinoma (OSCC), a subset of head and neck cancers, primarily originates in the epithelial tissues of the oral cavity. Despite advancements in treatment, the mortality rate for OSCC remains around 50%, underscoring the urgent need for improved prognostic markers. This review explores the role of the BRCA1 and BRCA2 genes—traditionally associated with breast and ovarian cancers—in the context of OSCC. We discuss the molecular pathways involving BRCA genes, their potential as diagnostics and prognostic biomarkers, and their implications for personalized treatment strategies, including addressing chemotherapy resistance. Furthermore, this review emphasizes the significance of genome stability in cancer progression and examines both current and emerging methodologies for detecting BRCA mutations in OSCC patients. Despite limited prevalence of BRCA mutations in OSCC compared to other cancers, their role in DNA repair and therapeutic response underscores their potential as clinical biomarkers. However, standardized, multicenter studies are still needed to validate their utility in OSCC management. A better understanding of the role of BRCA genes in OSCC could pave the way for more effective therapeutic approaches and improved patient outcomes.https://www.frontiersin.org/articles/10.3389/fonc.2025.1528822/fullBRCA1BRCA2OSCC (oral squamous cell carcinoma)HNSCC (head and neck squamous cell carcinoma)gene alteration |
| spellingShingle | Dominika Gedeonová Dominika Gedeonová Claretta Bianchi Claretta Bianchi Jan Štembírek Jan Štembírek Jan Štembírek Matouš Hrdinka Matouš Hrdinka Zuzana Chyra Zuzana Chyra Marcela Buchtová Marcela Buchtová Pavel Hurník Pavel Hurník Tomáš Blažek Jana Režnarová Jana Režnarová BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireview Frontiers in Oncology BRCA1 BRCA2 OSCC (oral squamous cell carcinoma) HNSCC (head and neck squamous cell carcinoma) gene alteration |
| title | BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireview |
| title_full | BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireview |
| title_fullStr | BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireview |
| title_full_unstemmed | BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireview |
| title_short | BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireview |
| title_sort | brca1 and brca2 as prognostic markers in oral squamous cell carcinoma a minireview |
| topic | BRCA1 BRCA2 OSCC (oral squamous cell carcinoma) HNSCC (head and neck squamous cell carcinoma) gene alteration |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1528822/full |
| work_keys_str_mv | AT dominikagedeonova brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT dominikagedeonova brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT clarettabianchi brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT clarettabianchi brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT janstembirek brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT janstembirek brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT janstembirek brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT matoushrdinka brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT matoushrdinka brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT zuzanachyra brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT zuzanachyra brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT marcelabuchtova brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT marcelabuchtova brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT pavelhurnik brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT pavelhurnik brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT tomasblazek brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT janareznarova brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview AT janareznarova brca1andbrca2asprognosticmarkersinoralsquamouscellcarcinomaaminireview |