AKT1 as a therapeutic target for platinum-resistant SOX2 positive ovarian cancer cells

AKT1 as a therapeutic target for platinum-resistant SOX2 positive ovarian cancer cells

Abstract Ovarian cancer remains the most lethal gynecological malignancy, largely owing to its chemotherapy resistance and high recurrence rate. Emerging evidence has linked the aberrant expression of SOX2, a transcription factor that is important in the development and maintenance of stem cell stat...

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Bibliographic Details
Main Authors: Mengyang Xue, Li Kang, Yunfeng Zhang, Xixia Yuan, Jiwen Li, Rong Zhang, Jiemin Wong
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Ovarian cancer
SOX2
AKT1
Protein stability
Chemotherapy
Online Access:https://doi.org/10.1038/s41598-025-92036-2
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