Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines
In this study, we investigated whether miR-125a participated in the resistance of the leukemia cell lines to the chemotherapeutic agent daunorubicin. Higher expression of miR-125a is correlated with lower treatment response and shorter overall survival in acute leukemia patients. Overexpression of m...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-04-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317695964 |
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| _version_ | 1849707551820611584 |
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| author | Haitao Bai Lili Zhou Chun Wang Xiaowei Xu Jieling Jiang Youwen Qin Xiaorui Wang Chuxian Zhao Shan Shao |
| author_facet | Haitao Bai Lili Zhou Chun Wang Xiaowei Xu Jieling Jiang Youwen Qin Xiaorui Wang Chuxian Zhao Shan Shao |
| author_sort | Haitao Bai |
| collection | DOAJ |
| description | In this study, we investigated whether miR-125a participated in the resistance of the leukemia cell lines to the chemotherapeutic agent daunorubicin. Higher expression of miR-125a is correlated with lower treatment response and shorter overall survival in acute leukemia patients. Overexpression of miR-125a induced drug resistance in HL-60, K562, and THP-1cell lines through reducing apoptosis. We also showed that miR-125a mediated daunorubicin resistance in leukemia cell lines through the decrease of GRK2 and Puma which were proved to be direct targets of miR-125a. This study may provide novel therapeutic targets for therapy and improve predictions of therapeutic responses in leukemia to daunorubicin. |
| format | Article |
| id | doaj-art-0f95e6fc0cd24b3aad5fa1f03215072a |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-0f95e6fc0cd24b3aad5fa1f03215072a2025-08-20T03:15:53ZengSAGE PublishingTumor Biology1423-03802017-04-013910.1177/1010428317695964Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell linesHaitao Bai0Lili Zhou1Chun Wang2Xiaowei Xu3Jieling Jiang4Youwen Qin5Xiaorui Wang6Chuxian Zhao7Shan Shao8Department of Hematology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, ChinaDepartment of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Hematology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, ChinaDepartment of Hematology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, ChinaDepartment of Hematology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, ChinaDepartment of Hematology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, ChinaDepartment of Hematology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, ChinaDepartment of Hematology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, ChinaDepartment of Hematology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, ChinaIn this study, we investigated whether miR-125a participated in the resistance of the leukemia cell lines to the chemotherapeutic agent daunorubicin. Higher expression of miR-125a is correlated with lower treatment response and shorter overall survival in acute leukemia patients. Overexpression of miR-125a induced drug resistance in HL-60, K562, and THP-1cell lines through reducing apoptosis. We also showed that miR-125a mediated daunorubicin resistance in leukemia cell lines through the decrease of GRK2 and Puma which were proved to be direct targets of miR-125a. This study may provide novel therapeutic targets for therapy and improve predictions of therapeutic responses in leukemia to daunorubicin.https://doi.org/10.1177/1010428317695964 |
| spellingShingle | Haitao Bai Lili Zhou Chun Wang Xiaowei Xu Jieling Jiang Youwen Qin Xiaorui Wang Chuxian Zhao Shan Shao Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines Tumor Biology |
| title | Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines |
| title_full | Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines |
| title_fullStr | Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines |
| title_full_unstemmed | Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines |
| title_short | Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines |
| title_sort | involvement of mir 125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines |
| url | https://doi.org/10.1177/1010428317695964 |
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