Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability‐Free Survival in Older People
Background The risk–benefit balance of statin use in healthy older people is uncertain. We describe the baseline characteristics of the STAREE (Statins in Reducing Events in the Elderly) trial, which is a randomized, double‐blind, placebo‐controlled trial among community‐dwelling older people; the t...
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Wiley
2024-11-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.036357 |
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| author | Sophia Zoungas Chris Moran Andrea J. Curtis Simone Spark Zachary Flanagan Lawrence Beilin Trevor T.‐J. Chong Geoffrey C. Cloud Ingrid Hopper Alissia Kost John J. McNeil Stephen J. Nicholls Christopher M. Reid Joanne Ryan Andrew M. Tonkin Stephanie Ward Anthony S. Wierzbicki Rory Wolfe Zhen Zhou Mark R. Nelson |
| author_facet | Sophia Zoungas Chris Moran Andrea J. Curtis Simone Spark Zachary Flanagan Lawrence Beilin Trevor T.‐J. Chong Geoffrey C. Cloud Ingrid Hopper Alissia Kost John J. McNeil Stephen J. Nicholls Christopher M. Reid Joanne Ryan Andrew M. Tonkin Stephanie Ward Anthony S. Wierzbicki Rory Wolfe Zhen Zhou Mark R. Nelson |
| author_sort | Sophia Zoungas |
| collection | DOAJ |
| description | Background The risk–benefit balance of statin use in healthy older people is uncertain. We describe the baseline characteristics of the STAREE (Statins in Reducing Events in the Elderly) trial, which is a randomized, double‐blind, placebo‐controlled trial among community‐dwelling older people; the trial evaluated the effect of atorvastatin 40 mg for the prevention of major cardiovascular events (cardiovascular death, nonfatal myocardial infarction or stroke), and on disability‐free survival (survival free of both dementia and persistent physical disability). Methods and Results STAREE enrolled people aged ≥70 years from 1583 general practices across Australia with no history of clinical cardiovascular disease, diabetes, or dementia. Baseline data collected included demographic, clinical, cognitive (Modified Mini‐Mental State Examination), psychological (Center for Epidemiologic Studies Short Depression Scale), lifestyle, medical, physical, blood and urine measures, and quality of life. Demographic and clinical characteristics of study participants were then compared with publicly available landmark statin trials. A total of 9971 participants were recruited (mean±SD age 74.7±4.5 years, 4023 (40%) ≥75 years, 52% women) between July 2015 and March 2023. The mean low‐density lipoprotein cholesterol was 3.27 mmol/L (SD=0.72; 126 mg/dL). Hypertension was reported by 43% of participants and the mean blood pressure was 136/80 mm Hg. Compared with previous landmark statin trials that included primary prevention cohorts, STAREE is unique in including such a large number of older (≥75 years) independent‐living people. Conclusions STAREE is the largest primary prevention trial of statins powered to address the important clinical outcomes of major cardiovascular events, disability‐free survival, and cognition in older people. Registration https://www.clinicaltrials.gov; Unique identifier: NCT02099123. |
| format | Article |
| id | doaj-art-0f943baeac03416d90ac362724f0bb84 |
| institution | Kabale University |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-0f943baeac03416d90ac362724f0bb842024-11-19T12:31:39ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-11-01132210.1161/JAHA.124.036357Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability‐Free Survival in Older PeopleSophia Zoungas0Chris Moran1Andrea J. Curtis2Simone Spark3Zachary Flanagan4Lawrence Beilin5Trevor T.‐J. Chong6Geoffrey C. Cloud7Ingrid Hopper8Alissia Kost9John J. McNeil10Stephen J. Nicholls11Christopher M. Reid12Joanne Ryan13Andrew M. Tonkin14Stephanie Ward15Anthony S. Wierzbicki16Rory Wolfe17Zhen Zhou18Mark R. Nelson19School of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Medicine Royal Perth Hospital, University of Western Australia Perth Western Australia AustraliaTurner Institute for Brain and Mental Health, School of Psychological Sciences Monash University Melbourne Victoria AustraliaDepartment of Neurology Alfred Health Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaDepartment of Metabolic Medicine/Chemical Pathology Guy’s & St Thomas’ Hospitals London United KingdomSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaBackground The risk–benefit balance of statin use in healthy older people is uncertain. We describe the baseline characteristics of the STAREE (Statins in Reducing Events in the Elderly) trial, which is a randomized, double‐blind, placebo‐controlled trial among community‐dwelling older people; the trial evaluated the effect of atorvastatin 40 mg for the prevention of major cardiovascular events (cardiovascular death, nonfatal myocardial infarction or stroke), and on disability‐free survival (survival free of both dementia and persistent physical disability). Methods and Results STAREE enrolled people aged ≥70 years from 1583 general practices across Australia with no history of clinical cardiovascular disease, diabetes, or dementia. Baseline data collected included demographic, clinical, cognitive (Modified Mini‐Mental State Examination), psychological (Center for Epidemiologic Studies Short Depression Scale), lifestyle, medical, physical, blood and urine measures, and quality of life. Demographic and clinical characteristics of study participants were then compared with publicly available landmark statin trials. A total of 9971 participants were recruited (mean±SD age 74.7±4.5 years, 4023 (40%) ≥75 years, 52% women) between July 2015 and March 2023. The mean low‐density lipoprotein cholesterol was 3.27 mmol/L (SD=0.72; 126 mg/dL). Hypertension was reported by 43% of participants and the mean blood pressure was 136/80 mm Hg. Compared with previous landmark statin trials that included primary prevention cohorts, STAREE is unique in including such a large number of older (≥75 years) independent‐living people. Conclusions STAREE is the largest primary prevention trial of statins powered to address the important clinical outcomes of major cardiovascular events, disability‐free survival, and cognition in older people. Registration https://www.clinicaltrials.gov; Unique identifier: NCT02099123.https://www.ahajournals.org/doi/10.1161/JAHA.124.036357primary preventionrandomized clinical trialstatins |
| spellingShingle | Sophia Zoungas Chris Moran Andrea J. Curtis Simone Spark Zachary Flanagan Lawrence Beilin Trevor T.‐J. Chong Geoffrey C. Cloud Ingrid Hopper Alissia Kost John J. McNeil Stephen J. Nicholls Christopher M. Reid Joanne Ryan Andrew M. Tonkin Stephanie Ward Anthony S. Wierzbicki Rory Wolfe Zhen Zhou Mark R. Nelson Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability‐Free Survival in Older People Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease primary prevention randomized clinical trial statins |
| title | Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability‐Free Survival in Older People |
| title_full | Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability‐Free Survival in Older People |
| title_fullStr | Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability‐Free Survival in Older People |
| title_full_unstemmed | Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability‐Free Survival in Older People |
| title_short | Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability‐Free Survival in Older People |
| title_sort | baseline characteristics of participants in staree a randomized trial for primary prevention of cardiovascular disease events and prolongation of disability free survival in older people |
| topic | primary prevention randomized clinical trial statins |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.036357 |
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