In Vivo Quantitative Ultrasound Image Analysis of Femoral Subchondral Bone in Knee Osteoarthritis
A potential of quantitative noninvasive knee ultrasonography (US) for detecting changes in femoral subchondral bone related to knee osteoarthritis (OA) was investigated. Thirty-nine patients referred to a knee arthroscopy underwent dynamic noninvasive US examination of the knee joint. The subchondra...
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/182562 |
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| author | Jana Podlipská Juhani M. Koski Pasi Pulkkinen Simo Saarakkala |
| author_facet | Jana Podlipská Juhani M. Koski Pasi Pulkkinen Simo Saarakkala |
| author_sort | Jana Podlipská |
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| description | A potential of quantitative noninvasive knee ultrasonography (US) for detecting changes in femoral subchondral bone related to knee osteoarthritis (OA) was investigated. Thirty-nine patients referred to a knee arthroscopy underwent dynamic noninvasive US examination of the knee joint. The subchondral bone was semiautomatically segmented from representative US images of femoral medial and lateral condyles and intercondylar notch area. Subsequently, the normalized mean gray-level intensity profile, starting from the cartilage-bone interface and extending to the subchondral bone depth of ~1.7 mm, was calculated. The obtained profile was divided into 5 depth levels and the mean of each level, as well as the slope of the profile within the first two levels, was calculated. The US quantitative data were compared with the arthroscopic Noyes’ grading and radiographic Kellgren-Lawrence (K-L) grading. Qualitatively, an increase in relative subchondral bone US gray-level values was observed as OA progressed. Statistically significant correlations were observed between normalized US mean intensity or intensity slope especially in subchondral bone depth level 2 and K-L grading (r=0.600, P<0.001; r=0.486, P=0.006, resp.) or femoral arthroscopic scoring (r=0.332, P=0.039; r=0.335, P=0.037, resp.). This novel quantitative noninvasive US analysis technique is promising for detection of femoral subchondral bone changes in knee OA. |
| format | Article |
| id | doaj-art-0f89101ddea44d159c62c884040bd710 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | The Scientific World Journal |
| spelling | doaj-art-0f89101ddea44d159c62c884040bd7102025-08-20T02:02:30ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/182562182562In Vivo Quantitative Ultrasound Image Analysis of Femoral Subchondral Bone in Knee OsteoarthritisJana Podlipská0Juhani M. Koski1Pasi Pulkkinen2Simo Saarakkala3Department of Medical Technology, University of Oulu, Aapistie 7A, P.O. Box 5000, 90014 Oulu, FinlandDepartment of Internal Medicine, Mikkeli Central Hospital, 50100 Mikkeli, FinlandDepartment of Medical Technology, University of Oulu, Aapistie 7A, P.O. Box 5000, 90014 Oulu, FinlandDepartment of Medical Technology, University of Oulu, Aapistie 7A, P.O. Box 5000, 90014 Oulu, FinlandA potential of quantitative noninvasive knee ultrasonography (US) for detecting changes in femoral subchondral bone related to knee osteoarthritis (OA) was investigated. Thirty-nine patients referred to a knee arthroscopy underwent dynamic noninvasive US examination of the knee joint. The subchondral bone was semiautomatically segmented from representative US images of femoral medial and lateral condyles and intercondylar notch area. Subsequently, the normalized mean gray-level intensity profile, starting from the cartilage-bone interface and extending to the subchondral bone depth of ~1.7 mm, was calculated. The obtained profile was divided into 5 depth levels and the mean of each level, as well as the slope of the profile within the first two levels, was calculated. The US quantitative data were compared with the arthroscopic Noyes’ grading and radiographic Kellgren-Lawrence (K-L) grading. Qualitatively, an increase in relative subchondral bone US gray-level values was observed as OA progressed. Statistically significant correlations were observed between normalized US mean intensity or intensity slope especially in subchondral bone depth level 2 and K-L grading (r=0.600, P<0.001; r=0.486, P=0.006, resp.) or femoral arthroscopic scoring (r=0.332, P=0.039; r=0.335, P=0.037, resp.). This novel quantitative noninvasive US analysis technique is promising for detection of femoral subchondral bone changes in knee OA.http://dx.doi.org/10.1155/2013/182562 |
| spellingShingle | Jana Podlipská Juhani M. Koski Pasi Pulkkinen Simo Saarakkala In Vivo Quantitative Ultrasound Image Analysis of Femoral Subchondral Bone in Knee Osteoarthritis The Scientific World Journal |
| title | In Vivo Quantitative Ultrasound Image Analysis of Femoral Subchondral Bone in Knee Osteoarthritis |
| title_full | In Vivo Quantitative Ultrasound Image Analysis of Femoral Subchondral Bone in Knee Osteoarthritis |
| title_fullStr | In Vivo Quantitative Ultrasound Image Analysis of Femoral Subchondral Bone in Knee Osteoarthritis |
| title_full_unstemmed | In Vivo Quantitative Ultrasound Image Analysis of Femoral Subchondral Bone in Knee Osteoarthritis |
| title_short | In Vivo Quantitative Ultrasound Image Analysis of Femoral Subchondral Bone in Knee Osteoarthritis |
| title_sort | in vivo quantitative ultrasound image analysis of femoral subchondral bone in knee osteoarthritis |
| url | http://dx.doi.org/10.1155/2013/182562 |
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