Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer
Despite significant advances in the detection and treatment of lung cancer, it causes the highest number of cancer-related mortality. Recent advances in the detection of genetic alterations in patient samples along with physiologically relevant animal models has yielded a new understanding of the mo...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/940405 |
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| author | Jackie L. Johnson Smitha Pillai Srikumar P. Chellappan |
| author_facet | Jackie L. Johnson Smitha Pillai Srikumar P. Chellappan |
| author_sort | Jackie L. Johnson |
| collection | DOAJ |
| description | Despite significant advances in the detection and treatment of lung cancer, it causes the highest number of cancer-related mortality. Recent advances in the detection of genetic alterations in patient samples along with physiologically relevant animal models has yielded a new understanding of the molecular etiology of lung cancer. This has facilitated the development of potent and specific targeted therapies, based on the genetic and biochemical alterations present in the tumor, especially non-small-cell lung cancer (NSCLC). It is now clear that heterogeneous cell signaling pathways are disrupted to promote NSCLC, including mutations in critical growth regulatory proteins (K-Ras, EGFR, B-RAF, MEK-1, HER2, MET, EML-4-ALK, KIF5B-RET, and NKX2.1) and inactivation of growth inhibitory pathways (TP53, PTEN, p16, and LKB-1). How these pathways differ between smokers and non-smokers is also important for clinical treatment strategies and development of targeted therapies. This paper describes these molecular targets in NSCLC, and describes the biological significance of each mutation and their potential to act as a therapeutic target. |
| format | Article |
| id | doaj-art-0f81bd29e2b347f5845bdba3236c04af |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-0f81bd29e2b347f5845bdba3236c04af2025-02-03T01:22:16ZengWileyBiochemistry Research International2090-22472090-22552012-01-01201210.1155/2012/940405940405Genetic and Biochemical Alterations in Non-Small Cell Lung CancerJackie L. Johnson0Smitha Pillai1Srikumar P. Chellappan2Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL 33612, USADepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USADepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USADespite significant advances in the detection and treatment of lung cancer, it causes the highest number of cancer-related mortality. Recent advances in the detection of genetic alterations in patient samples along with physiologically relevant animal models has yielded a new understanding of the molecular etiology of lung cancer. This has facilitated the development of potent and specific targeted therapies, based on the genetic and biochemical alterations present in the tumor, especially non-small-cell lung cancer (NSCLC). It is now clear that heterogeneous cell signaling pathways are disrupted to promote NSCLC, including mutations in critical growth regulatory proteins (K-Ras, EGFR, B-RAF, MEK-1, HER2, MET, EML-4-ALK, KIF5B-RET, and NKX2.1) and inactivation of growth inhibitory pathways (TP53, PTEN, p16, and LKB-1). How these pathways differ between smokers and non-smokers is also important for clinical treatment strategies and development of targeted therapies. This paper describes these molecular targets in NSCLC, and describes the biological significance of each mutation and their potential to act as a therapeutic target.http://dx.doi.org/10.1155/2012/940405 |
| spellingShingle | Jackie L. Johnson Smitha Pillai Srikumar P. Chellappan Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer Biochemistry Research International |
| title | Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer |
| title_full | Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer |
| title_fullStr | Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer |
| title_full_unstemmed | Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer |
| title_short | Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer |
| title_sort | genetic and biochemical alterations in non small cell lung cancer |
| url | http://dx.doi.org/10.1155/2012/940405 |
| work_keys_str_mv | AT jackieljohnson geneticandbiochemicalalterationsinnonsmallcelllungcancer AT smithapillai geneticandbiochemicalalterationsinnonsmallcelllungcancer AT srikumarpchellappan geneticandbiochemicalalterationsinnonsmallcelllungcancer |