Impact of Black Pepper (Piper nigrum) Powder on Lipid Profile Parameters Among Subjects with Non-Alcoholic Fatty Liver Disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD) is closely associated with dyslipidemia, a critical risk factor for cardiovascular diseases and metabolic disorders. This study examines the effects of supplementation of black pepper (Piper nigrum) which contains piperine a bioactive compound as its promine...
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EDP Sciences
2025-01-01
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| Series: | BIO Web of Conferences |
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| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/29/bioconf_amifost2025_02011.pdf |
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| author | Beenish Saxena Suyash Kifayat Mirza Shruti |
| author_facet | Beenish Saxena Suyash Kifayat Mirza Shruti |
| author_sort | Beenish |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is closely associated with dyslipidemia, a critical risk factor for cardiovascular diseases and metabolic disorders. This study examines the effects of supplementation of black pepper (Piper nigrum) which contains piperine a bioactive compound as its prominent constituent, on lipid profile parameters in NAFLD patients over 12 weeks. A randomized, double-blind, placebo-controlled trial was conducted with 170 clinically and radiologically diagnosed NAFLD patients. Participants were randomly allocated into a piperine supplementation group (n=85) and a placebo group (n=85). Lipid profile parameters, including total cholesterol, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were measured at baseline and post-intervention using enzymatic colorimetric analysis. The piperine group exhibited a significant reduction in total cholesterol, triglycerides, and LDL, along with a marked increase in HDL levels, whereas the placebo group showed no significant changes. Percent Changes in Lipid Profile (Piperine Group): Total Cholesterol ↓15.13%, Triglycerides ↓44.94%, LDL ↓21.58%, HDL ↑3.51%. The findings suggest that piperine supplementation could be an effective adjunct in managing lipid profiles in NAFLD patients, potentially reducing dyslipidemia-related complications. Further studies are required to assess long-term safety and underlying mechanisms. |
| format | Article |
| id | doaj-art-0f695897c0264d0aaba51981b3bd8a86 |
| institution | OA Journals |
| issn | 2117-4458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-0f695897c0264d0aaba51981b3bd8a862025-08-20T02:33:34ZengEDP SciencesBIO Web of Conferences2117-44582025-01-011780201110.1051/bioconf/202517802011bioconf_amifost2025_02011Impact of Black Pepper (Piper nigrum) Powder on Lipid Profile Parameters Among Subjects with Non-Alcoholic Fatty Liver Disease (NAFLD)Beenish0Saxena Suyash1Kifayat Mirza2Shruti3Research Scholar, Department of Nutrition and Dietetics, Sharda School of Allied Health Sciences, Sharda UniversityAssociate Professor, Department of Biochemistry, Sharda School of Allied Health Sciences, Sharda UniversityJunior Consultant, Department of Internal Medicine, Yatharth HospitalConsultant, Department of Internal Medicine, Yatharth HospitalNon-alcoholic fatty liver disease (NAFLD) is closely associated with dyslipidemia, a critical risk factor for cardiovascular diseases and metabolic disorders. This study examines the effects of supplementation of black pepper (Piper nigrum) which contains piperine a bioactive compound as its prominent constituent, on lipid profile parameters in NAFLD patients over 12 weeks. A randomized, double-blind, placebo-controlled trial was conducted with 170 clinically and radiologically diagnosed NAFLD patients. Participants were randomly allocated into a piperine supplementation group (n=85) and a placebo group (n=85). Lipid profile parameters, including total cholesterol, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were measured at baseline and post-intervention using enzymatic colorimetric analysis. The piperine group exhibited a significant reduction in total cholesterol, triglycerides, and LDL, along with a marked increase in HDL levels, whereas the placebo group showed no significant changes. Percent Changes in Lipid Profile (Piperine Group): Total Cholesterol ↓15.13%, Triglycerides ↓44.94%, LDL ↓21.58%, HDL ↑3.51%. The findings suggest that piperine supplementation could be an effective adjunct in managing lipid profiles in NAFLD patients, potentially reducing dyslipidemia-related complications. Further studies are required to assess long-term safety and underlying mechanisms.https://www.bio-conferences.org/articles/bioconf/pdf/2025/29/bioconf_amifost2025_02011.pdfdyslipidemialdltriglyceridespiperinenon-alcoholic steatohepatitis (nash) |
| spellingShingle | Beenish Saxena Suyash Kifayat Mirza Shruti Impact of Black Pepper (Piper nigrum) Powder on Lipid Profile Parameters Among Subjects with Non-Alcoholic Fatty Liver Disease (NAFLD) BIO Web of Conferences dyslipidemia ldl triglycerides piperine non-alcoholic steatohepatitis (nash) |
| title | Impact of Black Pepper (Piper nigrum) Powder on Lipid Profile Parameters Among Subjects with Non-Alcoholic Fatty Liver Disease (NAFLD) |
| title_full | Impact of Black Pepper (Piper nigrum) Powder on Lipid Profile Parameters Among Subjects with Non-Alcoholic Fatty Liver Disease (NAFLD) |
| title_fullStr | Impact of Black Pepper (Piper nigrum) Powder on Lipid Profile Parameters Among Subjects with Non-Alcoholic Fatty Liver Disease (NAFLD) |
| title_full_unstemmed | Impact of Black Pepper (Piper nigrum) Powder on Lipid Profile Parameters Among Subjects with Non-Alcoholic Fatty Liver Disease (NAFLD) |
| title_short | Impact of Black Pepper (Piper nigrum) Powder on Lipid Profile Parameters Among Subjects with Non-Alcoholic Fatty Liver Disease (NAFLD) |
| title_sort | impact of black pepper piper nigrum powder on lipid profile parameters among subjects with non alcoholic fatty liver disease nafld |
| topic | dyslipidemia ldl triglycerides piperine non-alcoholic steatohepatitis (nash) |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2025/29/bioconf_amifost2025_02011.pdf |
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