Liquid–liquid phase separation in hepatocellular carcinoma
Liquid-liquid phase separation (LLPS) drives the formation of membraneless intracellular compartments within both cytoplasm and nucleus. These compartments can form distinct physicochemical environments, and in particular display different concentrations of proteins, RNA, and macromolecules compared...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1454587/full |
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| author | Jianguo Xu Wangwang Liu Yihan Yao Tuomas P. J. Knowles Zhi-Gang Zhang Yan-Li Zhang |
| author_facet | Jianguo Xu Wangwang Liu Yihan Yao Tuomas P. J. Knowles Zhi-Gang Zhang Yan-Li Zhang |
| author_sort | Jianguo Xu |
| collection | DOAJ |
| description | Liquid-liquid phase separation (LLPS) drives the formation of membraneless intracellular compartments within both cytoplasm and nucleus. These compartments can form distinct physicochemical environments, and in particular display different concentrations of proteins, RNA, and macromolecules compared to the surrounding cytosol. Recent studies have highlighted the significant role of aberrant LLPS in cancer development and progression, impacting many core processes such as oncogenic signalling pathways, transcriptional dysregulation, and genome instability. In hepatocellular carcinoma (HCC), aberrant formation of biomolecular condensates has been observed in a number of preclinical models, highlighting their significance as an emerging factor in understanding cancer biology and its molecular underpinnings. In this review, we summarize emerging evidence and recent advances in understanding the role of LLPS in HCC, with a particular focus on the regulation and dysregulation of cytoplasmic and nuclear condensates in cancer cells. We finally discuss how an emerging understanding of phase separation processes in HCC opens up new potential treatment avenues. |
| format | Article |
| id | doaj-art-0f672bb5f41a4eedb0f3ae66a0bcd940 |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-0f672bb5f41a4eedb0f3ae66a0bcd9402025-08-20T02:00:06ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-12-011210.3389/fcell.2024.14545871454587Liquid–liquid phase separation in hepatocellular carcinomaJianguo Xu0Wangwang Liu1Yihan Yao2Tuomas P. J. Knowles3Zhi-Gang Zhang4Yan-Li Zhang5State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United KingdomYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United KingdomState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaLiquid-liquid phase separation (LLPS) drives the formation of membraneless intracellular compartments within both cytoplasm and nucleus. These compartments can form distinct physicochemical environments, and in particular display different concentrations of proteins, RNA, and macromolecules compared to the surrounding cytosol. Recent studies have highlighted the significant role of aberrant LLPS in cancer development and progression, impacting many core processes such as oncogenic signalling pathways, transcriptional dysregulation, and genome instability. In hepatocellular carcinoma (HCC), aberrant formation of biomolecular condensates has been observed in a number of preclinical models, highlighting their significance as an emerging factor in understanding cancer biology and its molecular underpinnings. In this review, we summarize emerging evidence and recent advances in understanding the role of LLPS in HCC, with a particular focus on the regulation and dysregulation of cytoplasmic and nuclear condensates in cancer cells. We finally discuss how an emerging understanding of phase separation processes in HCC opens up new potential treatment avenues.https://www.frontiersin.org/articles/10.3389/fcell.2024.1454587/fullliquid-liquid phase separationhepatocellular carcinomacytoplasmic condensatesnuclear condensatesdroplets |
| spellingShingle | Jianguo Xu Wangwang Liu Yihan Yao Tuomas P. J. Knowles Zhi-Gang Zhang Yan-Li Zhang Liquid–liquid phase separation in hepatocellular carcinoma Frontiers in Cell and Developmental Biology liquid-liquid phase separation hepatocellular carcinoma cytoplasmic condensates nuclear condensates droplets |
| title | Liquid–liquid phase separation in hepatocellular carcinoma |
| title_full | Liquid–liquid phase separation in hepatocellular carcinoma |
| title_fullStr | Liquid–liquid phase separation in hepatocellular carcinoma |
| title_full_unstemmed | Liquid–liquid phase separation in hepatocellular carcinoma |
| title_short | Liquid–liquid phase separation in hepatocellular carcinoma |
| title_sort | liquid liquid phase separation in hepatocellular carcinoma |
| topic | liquid-liquid phase separation hepatocellular carcinoma cytoplasmic condensates nuclear condensates droplets |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1454587/full |
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