Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb
Aging is a complex biological process influenced by genetic, environmental, and lifestyle factors, including diet and exercise. This process not only leads to visible signs of skin aging, such as wrinkles and elasticity loss, but also predisposes individuals to a spectrum of age-related diseases. Ox...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000416 |
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| author | Sabrina Burattini Federico Gianfanti Francesco Onesimo Sabrina Donati Zeppa Barbara Canonico Mariele Montanari Giovanna Panza Daniele Lopez Giosuè Annibalini Fabiana Fanelli Roberta Saltarelli Michele Mari Michele Retini Riham Osman Aghna Mariam Matteo Micucci Giovanni Caprioli Agnese Santanatoglia Deborah Agostini Michela Battistelli |
| author_facet | Sabrina Burattini Federico Gianfanti Francesco Onesimo Sabrina Donati Zeppa Barbara Canonico Mariele Montanari Giovanna Panza Daniele Lopez Giosuè Annibalini Fabiana Fanelli Roberta Saltarelli Michele Mari Michele Retini Riham Osman Aghna Mariam Matteo Micucci Giovanni Caprioli Agnese Santanatoglia Deborah Agostini Michela Battistelli |
| author_sort | Sabrina Burattini |
| collection | DOAJ |
| description | Aging is a complex biological process influenced by genetic, environmental, and lifestyle factors, including diet and exercise. This process not only leads to visible signs of skin aging, such as wrinkles and elasticity loss, but also predisposes individuals to a spectrum of age-related diseases. Oxidative stress and inflammation are key events driving this phenomenon. This study aims to delve into the antioxidative and protective potential of a rhizome extract from Curcuma caesia Roxb., a less explored species within the turmeric family, focusing on its effects on HaCaT cells subjected to UV radiation. Curcuma caesia Roxb. rhizome was extracted for a phytocomplex (CCRE). Through HPLC-ESI-MS/MS, the chemical analysis identified key phenolic compounds, including (−)-epicatechin, procyanidin B2, and p-coumaric acid. Human immortalized keratinocyte cell lines (HaCaT) were treated with CCRE in healthy and UVB-induced conditions to assess their impact on oxidative stress and aging. Results demonstrated a significant reduction in mitochondrial superoxide anion levels without affecting mitochondrial membrane potential, indicating enhanced cellular resilience to oxidative stress. Additionally, CCRE decreased UVB-induced IL-6 expression and IKK phosphorylation, which play a crucial role in inflammaging. Notably, CCRE treatment also improved cell viability upon UVB exposure and mitigated UVB-induced cell apoptosis, further underscoring its potential to preserve cellular integrity and function in relation to environmental stressors. CCRE chemical composition and biological effects position it as a potential ingredient for formulations and functional foods to combat the signs of skin aging and enhance overall skin health. |
| format | Article |
| id | doaj-art-0f5f4469020c48e1a633f848aaed5e1e |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-0f5f4469020c48e1a633f848aaed5e1e2025-02-09T05:00:00ZengElsevierJournal of Functional Foods1756-46462025-02-01125106699Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia RoxbSabrina Burattini0Federico Gianfanti1Francesco Onesimo2Sabrina Donati Zeppa3Barbara Canonico4Mariele Montanari5Giovanna Panza6Daniele Lopez7Giosuè Annibalini8Fabiana Fanelli9Roberta Saltarelli10Michele Mari11Michele Retini12Riham Osman13Aghna Mariam14Matteo Micucci15Giovanni Caprioli16Agnese Santanatoglia17Deborah Agostini18Michela Battistelli19Department of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, Italy; Corresponding authors at: Department of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, Italy.Department of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, Italy; Corresponding authors at: Department of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, Italy.Chemistry Interdisciplinary Project, School of Pharmacy, University of Camerino, 62032 Camerino, ItalyChemistry Interdisciplinary Project, School of Pharmacy, University of Camerino, 62032 Camerino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Urbino University Carlo Bo, 61029 Urbino, ItalyAging is a complex biological process influenced by genetic, environmental, and lifestyle factors, including diet and exercise. This process not only leads to visible signs of skin aging, such as wrinkles and elasticity loss, but also predisposes individuals to a spectrum of age-related diseases. Oxidative stress and inflammation are key events driving this phenomenon. This study aims to delve into the antioxidative and protective potential of a rhizome extract from Curcuma caesia Roxb., a less explored species within the turmeric family, focusing on its effects on HaCaT cells subjected to UV radiation. Curcuma caesia Roxb. rhizome was extracted for a phytocomplex (CCRE). Through HPLC-ESI-MS/MS, the chemical analysis identified key phenolic compounds, including (−)-epicatechin, procyanidin B2, and p-coumaric acid. Human immortalized keratinocyte cell lines (HaCaT) were treated with CCRE in healthy and UVB-induced conditions to assess their impact on oxidative stress and aging. Results demonstrated a significant reduction in mitochondrial superoxide anion levels without affecting mitochondrial membrane potential, indicating enhanced cellular resilience to oxidative stress. Additionally, CCRE decreased UVB-induced IL-6 expression and IKK phosphorylation, which play a crucial role in inflammaging. Notably, CCRE treatment also improved cell viability upon UVB exposure and mitigated UVB-induced cell apoptosis, further underscoring its potential to preserve cellular integrity and function in relation to environmental stressors. CCRE chemical composition and biological effects position it as a potential ingredient for formulations and functional foods to combat the signs of skin aging and enhance overall skin health.http://www.sciencedirect.com/science/article/pii/S1756464625000416NutraceuticalsCosmeceuticalsAgingBlue turmericPolyphenolsHaCaT cells |
| spellingShingle | Sabrina Burattini Federico Gianfanti Francesco Onesimo Sabrina Donati Zeppa Barbara Canonico Mariele Montanari Giovanna Panza Daniele Lopez Giosuè Annibalini Fabiana Fanelli Roberta Saltarelli Michele Mari Michele Retini Riham Osman Aghna Mariam Matteo Micucci Giovanni Caprioli Agnese Santanatoglia Deborah Agostini Michela Battistelli Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb Journal of Functional Foods Nutraceuticals Cosmeceuticals Aging Blue turmeric Polyphenols HaCaT cells |
| title | Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb |
| title_full | Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb |
| title_fullStr | Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb |
| title_full_unstemmed | Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb |
| title_short | Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb |
| title_sort | blue elixir of youth and wellness the multicomponent multitarget paradigm of curcuma caesia roxb |
| topic | Nutraceuticals Cosmeceuticals Aging Blue turmeric Polyphenols HaCaT cells |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000416 |
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