Determination of 14 Benzodiazepine Multiresidues in Aquaculture Environment by Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
In this study, an analytical method for the simultaneous determination of 14 benzodiazepine (BDZ) multiresidues in aquaculture environmental water and sediment was developed using ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS). The method uses an internal standar...
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MDPI AG
2025-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/4/775 |
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| author | Hongyang Guo Jianwu Chen Guangjun Jiang Yuqing Mei Zhiqiang Gong Mingdian Liu Jinping Li Jinhua Gan |
| author_facet | Hongyang Guo Jianwu Chen Guangjun Jiang Yuqing Mei Zhiqiang Gong Mingdian Liu Jinping Li Jinhua Gan |
| author_sort | Hongyang Guo |
| collection | DOAJ |
| description | In this study, an analytical method for the simultaneous determination of 14 benzodiazepine (BDZ) multiresidues in aquaculture environmental water and sediment was developed using ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS). The method uses an internal standard for quantification and achieves chromatographic separation and analysis within 11 min. The results of method validation showed that the recoveries of most analytes were in the range of 70–120% in water or sediment matrices, and the correlation coefficients of the 14 target chemistries were R<sup>2</sup> > 0.99, with relative standard deviations (RSD) < 15%. The limits of detection (LODs) and the limits of quantification (LOQs) were in the ranges of 0.002–0.01 μg/L and 0.01–0.03 μg/L for water and 0.01–0.5 μg/kg and 0.04–1 μg/kg for the sediment matrix. The method is simple and has high rapidity, high sensitivity, and low cost. It provides technical support for the simultaneous monitoring of BDZ residues in the aquaculture environment. |
| format | Article |
| id | doaj-art-0f5d0121f6e04d778b354e976fa50736 |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-0f5d0121f6e04d778b354e976fa507362025-08-20T03:12:01ZengMDPI AGMolecules1420-30492025-02-0130477510.3390/molecules30040775Determination of 14 Benzodiazepine Multiresidues in Aquaculture Environment by Ultra-High-Performance Liquid Chromatography–Tandem Mass SpectrometryHongyang Guo0Jianwu Chen1Guangjun Jiang2Yuqing Mei3Zhiqiang Gong4Mingdian Liu5Jinping Li6Jinhua Gan7School of Environmental Engineering, Wuhan Textile University, Wuhan 430073, ChinaYangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, ChinaSchool of Agriculture, Ludong University, Yantai 264025, ChinaYangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, ChinaYangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, ChinaYangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, ChinaSchool of Environmental Engineering, Wuhan Textile University, Wuhan 430073, ChinaYangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, ChinaIn this study, an analytical method for the simultaneous determination of 14 benzodiazepine (BDZ) multiresidues in aquaculture environmental water and sediment was developed using ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS). The method uses an internal standard for quantification and achieves chromatographic separation and analysis within 11 min. The results of method validation showed that the recoveries of most analytes were in the range of 70–120% in water or sediment matrices, and the correlation coefficients of the 14 target chemistries were R<sup>2</sup> > 0.99, with relative standard deviations (RSD) < 15%. The limits of detection (LODs) and the limits of quantification (LOQs) were in the ranges of 0.002–0.01 μg/L and 0.01–0.03 μg/L for water and 0.01–0.5 μg/kg and 0.04–1 μg/kg for the sediment matrix. The method is simple and has high rapidity, high sensitivity, and low cost. It provides technical support for the simultaneous monitoring of BDZ residues in the aquaculture environment.https://www.mdpi.com/1420-3049/30/4/775ultra-high-performance liquid chromatography–tandem mass spectrometrybenzodiazepinesaquaculture environmentmultiresidues |
| spellingShingle | Hongyang Guo Jianwu Chen Guangjun Jiang Yuqing Mei Zhiqiang Gong Mingdian Liu Jinping Li Jinhua Gan Determination of 14 Benzodiazepine Multiresidues in Aquaculture Environment by Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry Molecules ultra-high-performance liquid chromatography–tandem mass spectrometry benzodiazepines aquaculture environment multiresidues |
| title | Determination of 14 Benzodiazepine Multiresidues in Aquaculture Environment by Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry |
| title_full | Determination of 14 Benzodiazepine Multiresidues in Aquaculture Environment by Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry |
| title_fullStr | Determination of 14 Benzodiazepine Multiresidues in Aquaculture Environment by Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry |
| title_full_unstemmed | Determination of 14 Benzodiazepine Multiresidues in Aquaculture Environment by Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry |
| title_short | Determination of 14 Benzodiazepine Multiresidues in Aquaculture Environment by Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry |
| title_sort | determination of 14 benzodiazepine multiresidues in aquaculture environment by ultra high performance liquid chromatography tandem mass spectrometry |
| topic | ultra-high-performance liquid chromatography–tandem mass spectrometry benzodiazepines aquaculture environment multiresidues |
| url | https://www.mdpi.com/1420-3049/30/4/775 |
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