Formulation Optimization of Arecoline Patches
The response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/945168 |
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| _version_ | 1850235340861734912 |
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| author | Pao-Chu Wu Pi-Ju Tsai Shin-Chen Lin Yaw-Bin Huang |
| author_facet | Pao-Chu Wu Pi-Ju Tsai Shin-Chen Lin Yaw-Bin Huang |
| author_sort | Pao-Chu Wu |
| collection | DOAJ |
| description | The response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K30 (PVP), plasticizers (PEG 400), and drug. In addition, using terpenes as enhancers could increase the flux of the drug. Menthol showed the highest enhancement effect on the flux of arecoline. |
| format | Article |
| id | doaj-art-0f53d4e572c94a3295be8ba23574eaab |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0f53d4e572c94a3295be8ba23574eaab2025-08-20T02:02:17ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/945168945168Formulation Optimization of Arecoline PatchesPao-Chu Wu0Pi-Ju Tsai1Shin-Chen Lin2Yaw-Bin Huang3School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, TaiwanDepartment of Business Administration, I-Shou University, No. 1, Section 1, Syuecheng Road, Dashu, Kaohsiung 84001, TaiwanSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, TaiwanSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 80708, TaiwanThe response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K30 (PVP), plasticizers (PEG 400), and drug. In addition, using terpenes as enhancers could increase the flux of the drug. Menthol showed the highest enhancement effect on the flux of arecoline.http://dx.doi.org/10.1155/2014/945168 |
| spellingShingle | Pao-Chu Wu Pi-Ju Tsai Shin-Chen Lin Yaw-Bin Huang Formulation Optimization of Arecoline Patches The Scientific World Journal |
| title | Formulation Optimization of Arecoline Patches |
| title_full | Formulation Optimization of Arecoline Patches |
| title_fullStr | Formulation Optimization of Arecoline Patches |
| title_full_unstemmed | Formulation Optimization of Arecoline Patches |
| title_short | Formulation Optimization of Arecoline Patches |
| title_sort | formulation optimization of arecoline patches |
| url | http://dx.doi.org/10.1155/2014/945168 |
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