An Emerging Way for Bacteria to Engage with Host Cells via Protein ADP-riboxanation
Post-translational modifications (PTMs) are increasingly recognized as important strategies used by bacterial pathogens to modulate host cellular functions. Protein ADP-riboxanation, a derivative of ADP-ribosylation, has recently emerged as a new biochemical way by which bacterial pathogens interact...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/16/11/467 |
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| author | Wei Xian Zhiheng Tang Qinxin Zhang Ying Wang Xiaoyun Liu |
| author_facet | Wei Xian Zhiheng Tang Qinxin Zhang Ying Wang Xiaoyun Liu |
| author_sort | Wei Xian |
| collection | DOAJ |
| description | Post-translational modifications (PTMs) are increasingly recognized as important strategies used by bacterial pathogens to modulate host cellular functions. Protein ADP-riboxanation, a derivative of ADP-ribosylation, has recently emerged as a new biochemical way by which bacterial pathogens interact with host cells. Recent studies have revealed that this modification has broad regulatory roles in host processes including cell death, protein translation, and stress granule formation. Given that the vast majority of bacterial ADP-riboxanases are still uncharacterized, in this review we also highlight the utility of advanced proteomic tools in the functional dissection of ADP-riboxanation events during bacterial infections. |
| format | Article |
| id | doaj-art-0f4902ff78ee48a8b62af201580f940c |
| institution | OA Journals |
| issn | 2072-6651 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj-art-0f4902ff78ee48a8b62af201580f940c2025-08-20T02:27:40ZengMDPI AGToxins2072-66512024-11-01161146710.3390/toxins16110467An Emerging Way for Bacteria to Engage with Host Cells via Protein ADP-riboxanationWei Xian0Zhiheng Tang1Qinxin Zhang2Ying Wang3Xiaoyun Liu4Department of Microbiology and Infectious Disease Center, NHC Key Laboratory of Medical Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Microbiology and Infectious Disease Center, NHC Key Laboratory of Medical Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Microbiology and Infectious Disease Center, NHC Key Laboratory of Medical Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Microbiology and Infectious Disease Center, NHC Key Laboratory of Medical Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Microbiology and Infectious Disease Center, NHC Key Laboratory of Medical Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaPost-translational modifications (PTMs) are increasingly recognized as important strategies used by bacterial pathogens to modulate host cellular functions. Protein ADP-riboxanation, a derivative of ADP-ribosylation, has recently emerged as a new biochemical way by which bacterial pathogens interact with host cells. Recent studies have revealed that this modification has broad regulatory roles in host processes including cell death, protein translation, and stress granule formation. Given that the vast majority of bacterial ADP-riboxanases are still uncharacterized, in this review we also highlight the utility of advanced proteomic tools in the functional dissection of ADP-riboxanation events during bacterial infections.https://www.mdpi.com/2072-6651/16/11/467ADP-riboxanationADP-ribosylationpost-translational modificationsbacterial effectors |
| spellingShingle | Wei Xian Zhiheng Tang Qinxin Zhang Ying Wang Xiaoyun Liu An Emerging Way for Bacteria to Engage with Host Cells via Protein ADP-riboxanation Toxins ADP-riboxanation ADP-ribosylation post-translational modifications bacterial effectors |
| title | An Emerging Way for Bacteria to Engage with Host Cells via Protein ADP-riboxanation |
| title_full | An Emerging Way for Bacteria to Engage with Host Cells via Protein ADP-riboxanation |
| title_fullStr | An Emerging Way for Bacteria to Engage with Host Cells via Protein ADP-riboxanation |
| title_full_unstemmed | An Emerging Way for Bacteria to Engage with Host Cells via Protein ADP-riboxanation |
| title_short | An Emerging Way for Bacteria to Engage with Host Cells via Protein ADP-riboxanation |
| title_sort | emerging way for bacteria to engage with host cells via protein adp riboxanation |
| topic | ADP-riboxanation ADP-ribosylation post-translational modifications bacterial effectors |
| url | https://www.mdpi.com/2072-6651/16/11/467 |
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