Pathological and Inflammatory Consequences of Aging
Aging is a complex, progressive, and irreversible biological process that entails numerous structural and functional changes in the organism. These changes affect all bodily systems, reducing their ability to respond and adapt to the environment. Chronic inflammation is one of the key factors drivin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/3/404 |
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| author | Mario García-Domínguez |
| author_facet | Mario García-Domínguez |
| author_sort | Mario García-Domínguez |
| collection | DOAJ |
| description | Aging is a complex, progressive, and irreversible biological process that entails numerous structural and functional changes in the organism. These changes affect all bodily systems, reducing their ability to respond and adapt to the environment. Chronic inflammation is one of the key factors driving the development of age-related diseases, ultimately causing a substantial decline in the functional abilities of older individuals. This persistent inflammatory state (commonly known as “inflammaging”) is characterized by elevated levels of pro-inflammatory cytokines, an increase in oxidative stress, and a perturbation of immune homeostasis. Several factors, including cellular senescence, contribute to this inflammatory milieu, thereby amplifying conditions such as cardiovascular disease, neurodegeneration, and metabolic disorders. Exploring the mechanisms of chronic inflammation in aging is essential for developing targeted interventions aimed at promoting healthy aging. This review explains the strong connection between aging and chronic inflammation, highlighting potential therapeutic approaches like pharmacological treatments, dietary strategies, and lifestyle changes. |
| format | Article |
| id | doaj-art-0f481395da2f4677a39c355ab3c85acd |
| institution | DOAJ |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-0f481395da2f4677a39c355ab3c85acd2025-08-20T02:42:35ZengMDPI AGBiomolecules2218-273X2025-03-0115340410.3390/biom15030404Pathological and Inflammatory Consequences of AgingMario García-Domínguez0Program of Immunology and Immunotherapy, CIMA-Universidad de Navarra, 31008 Pamplona, SpainAging is a complex, progressive, and irreversible biological process that entails numerous structural and functional changes in the organism. These changes affect all bodily systems, reducing their ability to respond and adapt to the environment. Chronic inflammation is one of the key factors driving the development of age-related diseases, ultimately causing a substantial decline in the functional abilities of older individuals. This persistent inflammatory state (commonly known as “inflammaging”) is characterized by elevated levels of pro-inflammatory cytokines, an increase in oxidative stress, and a perturbation of immune homeostasis. Several factors, including cellular senescence, contribute to this inflammatory milieu, thereby amplifying conditions such as cardiovascular disease, neurodegeneration, and metabolic disorders. Exploring the mechanisms of chronic inflammation in aging is essential for developing targeted interventions aimed at promoting healthy aging. This review explains the strong connection between aging and chronic inflammation, highlighting potential therapeutic approaches like pharmacological treatments, dietary strategies, and lifestyle changes.https://www.mdpi.com/2218-273X/15/3/404inflammationinflammagingagingproteostasistelomere shorteningcellular senescence |
| spellingShingle | Mario García-Domínguez Pathological and Inflammatory Consequences of Aging Biomolecules inflammation inflammaging aging proteostasis telomere shortening cellular senescence |
| title | Pathological and Inflammatory Consequences of Aging |
| title_full | Pathological and Inflammatory Consequences of Aging |
| title_fullStr | Pathological and Inflammatory Consequences of Aging |
| title_full_unstemmed | Pathological and Inflammatory Consequences of Aging |
| title_short | Pathological and Inflammatory Consequences of Aging |
| title_sort | pathological and inflammatory consequences of aging |
| topic | inflammation inflammaging aging proteostasis telomere shortening cellular senescence |
| url | https://www.mdpi.com/2218-273X/15/3/404 |
| work_keys_str_mv | AT mariogarciadominguez pathologicalandinflammatoryconsequencesofaging |