Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy

Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy

Abstract Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and recurrence, along with a low sensitivity to immunotherapy, resulting in a paucity of effective therapeutic strategies. Herein, we have developed polydopamine-coated zinc-copper bimetallic nanoplatforms (Cu...

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Bibliographic Details
Main Authors: Bangyi Zhou, Mengyao Chen, Zhixing Hao, Lili Li, Yixin Zhang, Baoru Fang, Miner Shao, Guohong Ren, Ke Wang, Huiying Liu, Jingxuan Zhu, Xinyi Zhang, Shuyan Yuan, I Sitou, Jing Zhao, Jian Huang, Zhangsen Yu, Fuming Qiu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Nanobiotechnology
Subjects:
Triple-negative breast cancer
Immunotherapy
Cuproptosis
cGAS-STING signaling pathway
Photothermal therapy
Online Access:https://doi.org/10.1186/s12951-025-03186-4
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