Rising burden of cancer and atrial fibrillation–related mortality among adults in the United States, 1999–2019
Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia, whereas cancer remains the second leading cause of death in the United States. Both conditions share several risk factors and may compound mortality risk. However, national trends in AF and cancer-related mortality remain un...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
|
| Series: | Heart Rhythm O2 |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666501825001564 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849226841014927360 |
|---|---|
| author | Muhammad Saad, MBBS Reyan Hussain Shaikh, MBBS Muhammad Umer Sohail, MBBS Saad Ahmed Waqas, MBBS Mian Muinuddin Jamshed, MBBS Syed Ibad Ahsan, MBBS Muhammad Sameer Arshad, MBBS Azeem Hassan, MBBS Sebastian Mactaggart, MBBS Raheel Ahmed, MBBS, MRCP, PhD |
| author_facet | Muhammad Saad, MBBS Reyan Hussain Shaikh, MBBS Muhammad Umer Sohail, MBBS Saad Ahmed Waqas, MBBS Mian Muinuddin Jamshed, MBBS Syed Ibad Ahsan, MBBS Muhammad Sameer Arshad, MBBS Azeem Hassan, MBBS Sebastian Mactaggart, MBBS Raheel Ahmed, MBBS, MRCP, PhD |
| author_sort | Muhammad Saad, MBBS |
| collection | DOAJ |
| description | Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia, whereas cancer remains the second leading cause of death in the United States. Both conditions share several risk factors and may compound mortality risk. However, national trends in AF and cancer-related mortality remain underexplored. Objective: To assess trends in mortality related to AF and cancer among US adults from 1999 to 2019, using demographic and geographic stratifications. Methods: Data were obtained from the CDC WONDER Multiple Cause of Death data set. We identified individuals aged 25 years and older with AF (I48) and cancer (C00-C97) as an underlying or contributing cause of death. Age-adjusted mortality rates (AAMRs) per 100,000 population, average annual percentage change, and annual percentage change were calculated. Results: The AAMR for cancer and AF-related deaths increased from 4.95 (95% confidence interval [CI]: 4.84, 5.05) in 1999 to 10.01 (95% CI: 9.88, 10.13) in 2019 (average annual percentage change: 3.49 [95% CI: 3.39, 3.60]). Males had higher AAMRs than females (10.24 vs 5.13). Non-Hispanic Whites had the highest AAMRs (7.89), followed by non-Hispanic Blacks (4.53) and Hispanics (3.11). The Western region had the highest AAMR, and nonmetropolitan areas exhibited greater mortality rates than metropolitan areas. Individuals with lung cancer exhibited the highest AAMRs (1.65), followed by gastrointestinal cancer (1.52) and hematologic cancer (1.00). The lowest AAMRs were observed in prostate cancer (0.90) and breast cancer (0.65). Conclusion: Mortality from cancer and AF has increased over time, with significant disparities across sex, race, and geography. Targeted interventions are required to mitigate these disparities. |
| format | Article |
| id | doaj-art-0f3d09d67ae145d0bcab0dad40cfcd34 |
| institution | Kabale University |
| issn | 2666-5018 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heart Rhythm O2 |
| spelling | doaj-art-0f3d09d67ae145d0bcab0dad40cfcd342025-08-24T05:14:42ZengElsevierHeart Rhythm O22666-50182025-08-01681130113810.1016/j.hroo.2025.05.006Rising burden of cancer and atrial fibrillation–related mortality among adults in the United States, 1999–2019Muhammad Saad, MBBS0Reyan Hussain Shaikh, MBBS1Muhammad Umer Sohail, MBBS2Saad Ahmed Waqas, MBBS3Mian Muinuddin Jamshed, MBBS4Syed Ibad Ahsan, MBBS5Muhammad Sameer Arshad, MBBS6Azeem Hassan, MBBS7Sebastian Mactaggart, MBBS8Raheel Ahmed, MBBS, MRCP, PhD9Department of Medicine, Dow University of Health Sciences, Karachi, PakistanMedical College, Aga Khan University, Karachi, PakistanDepartment of Medicine, Dow University of Health Sciences, Karachi, PakistanDepartment of Medicine, Dow University of Health Sciences, Karachi, PakistanMedical College, Aga Khan University, Karachi, PakistanDepartment of Medicine, Dow University of Health Sciences, Karachi, PakistanBaylor Scott and White Research Institute, Dallas, TexasNational Heart and Lung Institute, Imperial College London, London, United KingdomNorthumbria Healthcare NHS Foundation Trust, North Shields, United KingdomNational Heart and Lung Institute, Imperial College London, London, United Kingdom; Address reprint requests and correspondence: Dr Raheel Ahmed, National Heart and Lung Institute, Imperial College London, London, United Kingdom.Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia, whereas cancer remains the second leading cause of death in the United States. Both conditions share several risk factors and may compound mortality risk. However, national trends in AF and cancer-related mortality remain underexplored. Objective: To assess trends in mortality related to AF and cancer among US adults from 1999 to 2019, using demographic and geographic stratifications. Methods: Data were obtained from the CDC WONDER Multiple Cause of Death data set. We identified individuals aged 25 years and older with AF (I48) and cancer (C00-C97) as an underlying or contributing cause of death. Age-adjusted mortality rates (AAMRs) per 100,000 population, average annual percentage change, and annual percentage change were calculated. Results: The AAMR for cancer and AF-related deaths increased from 4.95 (95% confidence interval [CI]: 4.84, 5.05) in 1999 to 10.01 (95% CI: 9.88, 10.13) in 2019 (average annual percentage change: 3.49 [95% CI: 3.39, 3.60]). Males had higher AAMRs than females (10.24 vs 5.13). Non-Hispanic Whites had the highest AAMRs (7.89), followed by non-Hispanic Blacks (4.53) and Hispanics (3.11). The Western region had the highest AAMR, and nonmetropolitan areas exhibited greater mortality rates than metropolitan areas. Individuals with lung cancer exhibited the highest AAMRs (1.65), followed by gastrointestinal cancer (1.52) and hematologic cancer (1.00). The lowest AAMRs were observed in prostate cancer (0.90) and breast cancer (0.65). Conclusion: Mortality from cancer and AF has increased over time, with significant disparities across sex, race, and geography. Targeted interventions are required to mitigate these disparities.http://www.sciencedirect.com/science/article/pii/S2666501825001564CancerAtrial fibrillationCDC WONDERMortality trendsDisparities |
| spellingShingle | Muhammad Saad, MBBS Reyan Hussain Shaikh, MBBS Muhammad Umer Sohail, MBBS Saad Ahmed Waqas, MBBS Mian Muinuddin Jamshed, MBBS Syed Ibad Ahsan, MBBS Muhammad Sameer Arshad, MBBS Azeem Hassan, MBBS Sebastian Mactaggart, MBBS Raheel Ahmed, MBBS, MRCP, PhD Rising burden of cancer and atrial fibrillation–related mortality among adults in the United States, 1999–2019 Heart Rhythm O2 Cancer Atrial fibrillation CDC WONDER Mortality trends Disparities |
| title | Rising burden of cancer and atrial fibrillation–related mortality among adults in the United States, 1999–2019 |
| title_full | Rising burden of cancer and atrial fibrillation–related mortality among adults in the United States, 1999–2019 |
| title_fullStr | Rising burden of cancer and atrial fibrillation–related mortality among adults in the United States, 1999–2019 |
| title_full_unstemmed | Rising burden of cancer and atrial fibrillation–related mortality among adults in the United States, 1999–2019 |
| title_short | Rising burden of cancer and atrial fibrillation–related mortality among adults in the United States, 1999–2019 |
| title_sort | rising burden of cancer and atrial fibrillation related mortality among adults in the united states 1999 2019 |
| topic | Cancer Atrial fibrillation CDC WONDER Mortality trends Disparities |
| url | http://www.sciencedirect.com/science/article/pii/S2666501825001564 |
| work_keys_str_mv | AT muhammadsaadmbbs risingburdenofcancerandatrialfibrillationrelatedmortalityamongadultsintheunitedstates19992019 AT reyanhussainshaikhmbbs risingburdenofcancerandatrialfibrillationrelatedmortalityamongadultsintheunitedstates19992019 AT muhammadumersohailmbbs risingburdenofcancerandatrialfibrillationrelatedmortalityamongadultsintheunitedstates19992019 AT saadahmedwaqasmbbs risingburdenofcancerandatrialfibrillationrelatedmortalityamongadultsintheunitedstates19992019 AT mianmuinuddinjamshedmbbs risingburdenofcancerandatrialfibrillationrelatedmortalityamongadultsintheunitedstates19992019 AT syedibadahsanmbbs risingburdenofcancerandatrialfibrillationrelatedmortalityamongadultsintheunitedstates19992019 AT muhammadsameerarshadmbbs risingburdenofcancerandatrialfibrillationrelatedmortalityamongadultsintheunitedstates19992019 AT azeemhassanmbbs risingburdenofcancerandatrialfibrillationrelatedmortalityamongadultsintheunitedstates19992019 AT sebastianmactaggartmbbs risingburdenofcancerandatrialfibrillationrelatedmortalityamongadultsintheunitedstates19992019 AT raheelahmedmbbsmrcpphd risingburdenofcancerandatrialfibrillationrelatedmortalityamongadultsintheunitedstates19992019 |