Analysis of risk factors for vitreous hemorrhage and recurrent hemorrhage after vitrectomy in patients with diabetic retinopathy
Abstract Purpose To investigate the risk factors associated with recurrent hemorrhage following vitrectomy surgical intervention for diabetic retinopathy (DR). Methods A retrospective analysis was conducted on 579 eyes diagnosed with DR necessitating surgical intervention. These cases were categoriz...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-025-04112-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849728288167034880 |
|---|---|
| author | Shuwen Lu Haoyu Li Chao Ma Xian Li |
| author_facet | Shuwen Lu Haoyu Li Chao Ma Xian Li |
| author_sort | Shuwen Lu |
| collection | DOAJ |
| description | Abstract Purpose To investigate the risk factors associated with recurrent hemorrhage following vitrectomy surgical intervention for diabetic retinopathy (DR). Methods A retrospective analysis was conducted on 579 eyes diagnosed with DR necessitating surgical intervention. These cases were categorized into two groups: recurrent hemorrhage and non-recurrent hemorrhage. Comparative, random forest (RF), and regression analyses were subsequently performed to evaluate variables pertaining to patients’ demographic information, clinical examination and blood test results, treatment approaches, lifestyle habits, and overall health status. Results This study compared patients with recurrent and non-recurrent hemorrhages, revealing significant differences in factors such as endodiathermy, anticoagulant use, cerebrovascular diseases, smoking status, glycosylated hemoglobin levels and BMI. Patients with no recurrent hemorrhage have faster vision recovery. The univariable logistic regression analysis indicated that cerebrovascular disease (OR = 7.87, P < 0.001), anticoagulant use (OR = 16.72, P < 0.001), and elevated glycated hemoglobin levels (OR = 21.22, P < 0.001) exhibited strong associations with recurrent hemorrhage. The multivariable logistic regression analysis indicated that recurrent hemorrhage risk factors include anticoagulant use (OR = 120.77, P = 0.020) and glycated hemoglobin levels (OR = 18.41, P = 0.001). Conclusions Recurrent postoperative hemorrhage is influenced by several factors, notably the use of intraoperative endodiathermy, adjustments in ocular therapy, and management of the patient’s systemic condition. In clinical practice, careful consideration of these factors is essential to mitigate postoperative hemorrhage in patients. |
| format | Article |
| id | doaj-art-0f39cfec6c8548509b3e87335598301e |
| institution | DOAJ |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-0f39cfec6c8548509b3e87335598301e2025-08-20T03:09:35ZengBMCBMC Ophthalmology1471-24152025-05-0125111010.1186/s12886-025-04112-wAnalysis of risk factors for vitreous hemorrhage and recurrent hemorrhage after vitrectomy in patients with diabetic retinopathyShuwen Lu0Haoyu Li1Chao Ma2Xian Li3Department of Ophthalmology, The First Affiliated Hospital of Henan University of Chinese MedicineDepartment of Ophthalmology, The Second Xiangya Hospital of Central South UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Zhengzhou UniversityManchester Royal Eye Hospital, Manchester University NHS Foundation TrustAbstract Purpose To investigate the risk factors associated with recurrent hemorrhage following vitrectomy surgical intervention for diabetic retinopathy (DR). Methods A retrospective analysis was conducted on 579 eyes diagnosed with DR necessitating surgical intervention. These cases were categorized into two groups: recurrent hemorrhage and non-recurrent hemorrhage. Comparative, random forest (RF), and regression analyses were subsequently performed to evaluate variables pertaining to patients’ demographic information, clinical examination and blood test results, treatment approaches, lifestyle habits, and overall health status. Results This study compared patients with recurrent and non-recurrent hemorrhages, revealing significant differences in factors such as endodiathermy, anticoagulant use, cerebrovascular diseases, smoking status, glycosylated hemoglobin levels and BMI. Patients with no recurrent hemorrhage have faster vision recovery. The univariable logistic regression analysis indicated that cerebrovascular disease (OR = 7.87, P < 0.001), anticoagulant use (OR = 16.72, P < 0.001), and elevated glycated hemoglobin levels (OR = 21.22, P < 0.001) exhibited strong associations with recurrent hemorrhage. The multivariable logistic regression analysis indicated that recurrent hemorrhage risk factors include anticoagulant use (OR = 120.77, P = 0.020) and glycated hemoglobin levels (OR = 18.41, P = 0.001). Conclusions Recurrent postoperative hemorrhage is influenced by several factors, notably the use of intraoperative endodiathermy, adjustments in ocular therapy, and management of the patient’s systemic condition. In clinical practice, careful consideration of these factors is essential to mitigate postoperative hemorrhage in patients.https://doi.org/10.1186/s12886-025-04112-wDiabetic retinopathyVitreous hemorrhageRecurrent hemorrhageEndodiathermyRisk factors |
| spellingShingle | Shuwen Lu Haoyu Li Chao Ma Xian Li Analysis of risk factors for vitreous hemorrhage and recurrent hemorrhage after vitrectomy in patients with diabetic retinopathy BMC Ophthalmology Diabetic retinopathy Vitreous hemorrhage Recurrent hemorrhage Endodiathermy Risk factors |
| title | Analysis of risk factors for vitreous hemorrhage and recurrent hemorrhage after vitrectomy in patients with diabetic retinopathy |
| title_full | Analysis of risk factors for vitreous hemorrhage and recurrent hemorrhage after vitrectomy in patients with diabetic retinopathy |
| title_fullStr | Analysis of risk factors for vitreous hemorrhage and recurrent hemorrhage after vitrectomy in patients with diabetic retinopathy |
| title_full_unstemmed | Analysis of risk factors for vitreous hemorrhage and recurrent hemorrhage after vitrectomy in patients with diabetic retinopathy |
| title_short | Analysis of risk factors for vitreous hemorrhage and recurrent hemorrhage after vitrectomy in patients with diabetic retinopathy |
| title_sort | analysis of risk factors for vitreous hemorrhage and recurrent hemorrhage after vitrectomy in patients with diabetic retinopathy |
| topic | Diabetic retinopathy Vitreous hemorrhage Recurrent hemorrhage Endodiathermy Risk factors |
| url | https://doi.org/10.1186/s12886-025-04112-w |
| work_keys_str_mv | AT shuwenlu analysisofriskfactorsforvitreoushemorrhageandrecurrenthemorrhageaftervitrectomyinpatientswithdiabeticretinopathy AT haoyuli analysisofriskfactorsforvitreoushemorrhageandrecurrenthemorrhageaftervitrectomyinpatientswithdiabeticretinopathy AT chaoma analysisofriskfactorsforvitreoushemorrhageandrecurrenthemorrhageaftervitrectomyinpatientswithdiabeticretinopathy AT xianli analysisofriskfactorsforvitreoushemorrhageandrecurrenthemorrhageaftervitrectomyinpatientswithdiabeticretinopathy |