The Predictive Effects of Atherogenic Indices and Remnant Cholesterol on Gestational Diabetes Mellitus Risk
Yao Cheng,1,* Jieping Song,2,* Lei Zhao,1,* Jieyun Yin,3 Xinfeng Lu,4 Yun Zhao,1 Guoqiang Sun1 1Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China; 2Medical Genetics Center, Maternal and Child Heal...
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Dove Medical Press
2025-07-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| author | Cheng Y Song J Zhao L Yin J Lu X Zhao Y Sun G |
| author_facet | Cheng Y Song J Zhao L Yin J Lu X Zhao Y Sun G |
| author_sort | Cheng Y |
| collection | DOAJ |
| description | Yao Cheng,1,* Jieping Song,2,* Lei Zhao,1,* Jieyun Yin,3 Xinfeng Lu,4 Yun Zhao,1 Guoqiang Sun1 1Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China; 2Medical Genetics Center, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China; 3Department of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 4Medical Record Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guoqiang Sun, Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuluo Road No. 745, Hongshan District, Wuhan, 430070, People’s Republic of China, Email sunguoqiang@hbfy.com Yun Zhao, Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuluo Road No. 745, Hongshan District, Wuhan, 430070, People’s Republic of China, Email zhao020060@163.comPurpose: This study aimed to investigate the predictive effects of atherogenic indices and remnant cholesterol on the risk of GDM.Patients and Methods: This observational study was conducted based on the Hospital’s clinical information system. A total of 6619 participants including 2054 GDM patients and 4565 controls were obtained. Serum lipid data, including triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL−C), and low-density lipoprotein cholesterol (LDL−C) levels were collected. Atherogenic indices including TG/HDL−C, TC/HDL−C, and LDL−C/HDL−C, and remnant cholesterol were regarded as independent variables, and GDM was regarded as the dependent variable. Logistic regression analyses, nomogram analysis, decision curve analysis (DCA), and restricted cubic spline (RCS) analysis were applied to explore the impact of atherogenic indices and remnant cholesterol on GDM.Results: The prevalence of GDM was 31.03% in this study. In comparison to the 1st quartile, the 4th quartile levels of atherogenic indices and remnant cholesterols were significantly associated with increased risks of gestational diabetes mellitus (GDM). The odds ratios (OR) for these associations were as follows: OR = 1.66 (95% CI: 1.41, 1.96) for TG/HDL−C; OR = 1.47 (95% CI: 1.24, 1.73) for TC/HDL−C; OR = 1.47 (95% CI: 1.24, 1.73) for LDL−C/HDL−C; and OR = 1.39 (95% CI: 1.18, 1.64) for remnant cholesterol. The DCA results confirmed the reliable clinical utility of GDM prediction by atherogenic indices and remnant cholesterol. The RCS regression analysis revealed the nonlinear relationships between the atherogenic indices, remnant cholesterol and GDM.Conclusion: This study revealed the potential predictive effects of atherogenic indices and remnant cholesterol on GDM. These findings underscore the potential of routine lipid testing as a cost-effective strategy for the early identification and management of GDM in clinical settings.Keywords: gestational diabetes mellitus, lipid index, atherogenic index, remnant cholesterol, dyslipidemia |
| format | Article |
| id | doaj-art-0f39bf8a661b48859fab80c689649cd5 |
| institution | DOAJ |
| issn | 1178-7007 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj-art-0f39bf8a661b48859fab80c689649cd52025-08-20T03:15:13ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072025-07-01Volume 18Issue 121072117104381The Predictive Effects of Atherogenic Indices and Remnant Cholesterol on Gestational Diabetes Mellitus RiskCheng Y0Song J1Zhao L2Yin J3Lu X4Zhao Y5Sun G6Obstetrics DepartmentMedical Genetics CenterObstetrics DepartmentDepartment of Epidemiology and Health StatisticsMedical Record DepartmentObstetrics DepartmentObstetrics DepartmentYao Cheng,1,* Jieping Song,2,* Lei Zhao,1,* Jieyun Yin,3 Xinfeng Lu,4 Yun Zhao,1 Guoqiang Sun1 1Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China; 2Medical Genetics Center, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China; 3Department of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 4Medical Record Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guoqiang Sun, Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuluo Road No. 745, Hongshan District, Wuhan, 430070, People’s Republic of China, Email sunguoqiang@hbfy.com Yun Zhao, Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuluo Road No. 745, Hongshan District, Wuhan, 430070, People’s Republic of China, Email zhao020060@163.comPurpose: This study aimed to investigate the predictive effects of atherogenic indices and remnant cholesterol on the risk of GDM.Patients and Methods: This observational study was conducted based on the Hospital’s clinical information system. A total of 6619 participants including 2054 GDM patients and 4565 controls were obtained. Serum lipid data, including triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL−C), and low-density lipoprotein cholesterol (LDL−C) levels were collected. Atherogenic indices including TG/HDL−C, TC/HDL−C, and LDL−C/HDL−C, and remnant cholesterol were regarded as independent variables, and GDM was regarded as the dependent variable. Logistic regression analyses, nomogram analysis, decision curve analysis (DCA), and restricted cubic spline (RCS) analysis were applied to explore the impact of atherogenic indices and remnant cholesterol on GDM.Results: The prevalence of GDM was 31.03% in this study. In comparison to the 1st quartile, the 4th quartile levels of atherogenic indices and remnant cholesterols were significantly associated with increased risks of gestational diabetes mellitus (GDM). The odds ratios (OR) for these associations were as follows: OR = 1.66 (95% CI: 1.41, 1.96) for TG/HDL−C; OR = 1.47 (95% CI: 1.24, 1.73) for TC/HDL−C; OR = 1.47 (95% CI: 1.24, 1.73) for LDL−C/HDL−C; and OR = 1.39 (95% CI: 1.18, 1.64) for remnant cholesterol. The DCA results confirmed the reliable clinical utility of GDM prediction by atherogenic indices and remnant cholesterol. The RCS regression analysis revealed the nonlinear relationships between the atherogenic indices, remnant cholesterol and GDM.Conclusion: This study revealed the potential predictive effects of atherogenic indices and remnant cholesterol on GDM. These findings underscore the potential of routine lipid testing as a cost-effective strategy for the early identification and management of GDM in clinical settings.Keywords: gestational diabetes mellitus, lipid index, atherogenic index, remnant cholesterol, dyslipidemiahttps://www.dovepress.com/the-predictive-effects-of-atherogenic-indices-and-remnant-cholesterol--peer-reviewed-fulltext-article-DMSOgestational diabetes mellituslipid indexatherogenic indexremnant cholesteroldyslipidemia |
| spellingShingle | Cheng Y Song J Zhao L Yin J Lu X Zhao Y Sun G The Predictive Effects of Atherogenic Indices and Remnant Cholesterol on Gestational Diabetes Mellitus Risk Diabetes, Metabolic Syndrome and Obesity gestational diabetes mellitus lipid index atherogenic index remnant cholesterol dyslipidemia |
| title | The Predictive Effects of Atherogenic Indices and Remnant Cholesterol on Gestational Diabetes Mellitus Risk |
| title_full | The Predictive Effects of Atherogenic Indices and Remnant Cholesterol on Gestational Diabetes Mellitus Risk |
| title_fullStr | The Predictive Effects of Atherogenic Indices and Remnant Cholesterol on Gestational Diabetes Mellitus Risk |
| title_full_unstemmed | The Predictive Effects of Atherogenic Indices and Remnant Cholesterol on Gestational Diabetes Mellitus Risk |
| title_short | The Predictive Effects of Atherogenic Indices and Remnant Cholesterol on Gestational Diabetes Mellitus Risk |
| title_sort | predictive effects of atherogenic indices and remnant cholesterol on gestational diabetes mellitus risk |
| topic | gestational diabetes mellitus lipid index atherogenic index remnant cholesterol dyslipidemia |
| url | https://www.dovepress.com/the-predictive-effects-of-atherogenic-indices-and-remnant-cholesterol--peer-reviewed-fulltext-article-DMSO |
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