Enhancing translational medical research through proof-of-concept services: clinicians’ perspectives
Abstract Although the proof-of-concept (POC) phase is critical for the success of translational medical research (TMR), its use remains limited, and clinicians are frequently uncertain about how to seek assistance from POC teams when experiencing difficulties with TMR. Therefore, this study explored...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-82401-y |
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| author | Lei Yuan Pan Zhao Jiandong Zhang Xiaoxiong Xu Mingliang Jin Ziyu Fang Chunya Wang Meina Li |
| author_facet | Lei Yuan Pan Zhao Jiandong Zhang Xiaoxiong Xu Mingliang Jin Ziyu Fang Chunya Wang Meina Li |
| author_sort | Lei Yuan |
| collection | DOAJ |
| description | Abstract Although the proof-of-concept (POC) phase is critical for the success of translational medical research (TMR), its use remains limited, and clinicians are frequently uncertain about how to seek assistance from POC teams when experiencing difficulties with TMR. Therefore, this study explored clinicians’ awareness of POC and the supportive reference services offered by POC teams. We distributed an internet-based questionnaire to 702 clinicians who conducted TMR between August 2022 and March 2023. Descriptive statistics, chi-square test, Wilcoxon rank sum test, Kruskal–Wallis rank sum test, and stepwise logistic regression analysis were applied. Clinicians’ awareness of POC was low (69.23%). However, young clinicians (aged 21–30 years) with a higher educational level than their colleagues, good understanding of POC, reliance on the hospital’s TMR policy and serviceability, and need or great need for services to identify suitable technology, literature, and intelligence services were likely to choose ‘agree’ over ‘disagree’ regarding the ability for POC services to help solve difficulties with TMR. Favourable conditions should be created to encourage clinicians to fully use POC services, and clinicians should actively acquire POC knowledge to enhance their understanding of the value of POC services in TMR. Notably, promoting the establishment of POC centres or platforms at the national level would facilitate the use of POC services by clinicians conducting TMR. |
| format | Article |
| id | doaj-art-0f3973599cb3433ea437afa76d4c2e16 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-0f3973599cb3433ea437afa76d4c2e162025-08-20T02:43:36ZengNature PortfolioScientific Reports2045-23222024-12-011411910.1038/s41598-024-82401-yEnhancing translational medical research through proof-of-concept services: clinicians’ perspectivesLei Yuan0Pan Zhao1Jiandong Zhang2Xiaoxiong Xu3Mingliang Jin4Ziyu Fang5Chunya Wang6Meina Li7Department of Health Management, Faculty of Military Health Services, Naval Medical UniversityThe Fifth Medical Center, Chinese PLA General HospitalTranslational Medicine Research Center, Naval Medical UniversityNaval Medical Center, Naval Medical University908 Hospital of PLA Joint Logistics Support ForceDepartment of Urology, The First Affiliated Hospital of Naval Medical UniversityCoronary Heart Disease Center, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Military Medical Services, Faculty of Military Health Services, Naval Medical UniversityAbstract Although the proof-of-concept (POC) phase is critical for the success of translational medical research (TMR), its use remains limited, and clinicians are frequently uncertain about how to seek assistance from POC teams when experiencing difficulties with TMR. Therefore, this study explored clinicians’ awareness of POC and the supportive reference services offered by POC teams. We distributed an internet-based questionnaire to 702 clinicians who conducted TMR between August 2022 and March 2023. Descriptive statistics, chi-square test, Wilcoxon rank sum test, Kruskal–Wallis rank sum test, and stepwise logistic regression analysis were applied. Clinicians’ awareness of POC was low (69.23%). However, young clinicians (aged 21–30 years) with a higher educational level than their colleagues, good understanding of POC, reliance on the hospital’s TMR policy and serviceability, and need or great need for services to identify suitable technology, literature, and intelligence services were likely to choose ‘agree’ over ‘disagree’ regarding the ability for POC services to help solve difficulties with TMR. Favourable conditions should be created to encourage clinicians to fully use POC services, and clinicians should actively acquire POC knowledge to enhance their understanding of the value of POC services in TMR. Notably, promoting the establishment of POC centres or platforms at the national level would facilitate the use of POC services by clinicians conducting TMR.https://doi.org/10.1038/s41598-024-82401-yProof-of-conceptTranslational medicineTranslational medical researchTranslational research |
| spellingShingle | Lei Yuan Pan Zhao Jiandong Zhang Xiaoxiong Xu Mingliang Jin Ziyu Fang Chunya Wang Meina Li Enhancing translational medical research through proof-of-concept services: clinicians’ perspectives Scientific Reports Proof-of-concept Translational medicine Translational medical research Translational research |
| title | Enhancing translational medical research through proof-of-concept services: clinicians’ perspectives |
| title_full | Enhancing translational medical research through proof-of-concept services: clinicians’ perspectives |
| title_fullStr | Enhancing translational medical research through proof-of-concept services: clinicians’ perspectives |
| title_full_unstemmed | Enhancing translational medical research through proof-of-concept services: clinicians’ perspectives |
| title_short | Enhancing translational medical research through proof-of-concept services: clinicians’ perspectives |
| title_sort | enhancing translational medical research through proof of concept services clinicians perspectives |
| topic | Proof-of-concept Translational medicine Translational medical research Translational research |
| url | https://doi.org/10.1038/s41598-024-82401-y |
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