Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD

Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD

Abstract Background Regulation of messenger RNA (mRNA) transport and translation in neurons is essential for dendritic plasticity and learning/memory development. The trafficking of mRNAs along the hippocampal neuron dendrites remains translationally silent until they are selectively transported int...

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Main Authors: Pritha Majumder, Biswanath Chatterjee, Khadiza Akter, Asmar Ahsan, Su Jie Tan, Chi-Chen Huang, Jen-Fei Chu, Che-Kun James Shen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cellular & Molecular Biology Letters
Subjects:
TDP-43
pFMRP (S499)
mRNP granule
RNA binding protein (RBP)
Posttranslational modification
Kinase
Online Access:https://doi.org/10.1186/s11658-024-00684-5
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