Modern approaches to interpretation of clinical trial results to evaluate the effectiveness of heart failure therapy. Analysis of the results of randomized trials PARADIGM-HF, DAPA-HF, EMPEROR-Reduced and VICTORIA
The article discusses the results of modern studies evaluating the effectiveness of drug therapy for heart failure with reduced ejection fraction (HFrEF). Modern approaches to a comprehensive evaluation of data obtained in various randomized clinical trials (RCTs) are presented. The role of methods...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2023-06-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5422 |
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| author | S. R. Gilyarevsky Yu. V. Mareev |
| author_facet | S. R. Gilyarevsky Yu. V. Mareev |
| author_sort | S. R. Gilyarevsky |
| collection | DOAJ |
| description | The article discusses the results of modern studies evaluating the effectiveness of drug therapy for heart failure with reduced ejection fraction (HFrEF). Modern approaches to a comprehensive evaluation of data obtained in various randomized clinical trials (RCTs) are presented. The role of methods for presenting the RCT results is considered, as well as the difference between hazard ratio and relative risk is clarified. Expert opinions are discussed about the limitations of simplified approaches to comparing the results of large RCTs, which are based only on comparisons of hazard ratio without taking consideration of patient characteristics, study duration, and the absolute number of adverse outcomes that developed. Information is provided on the role of accounting for multiple comparisons in assessing clinical outcomes in RCTs. The article compares the VICTORIA results on the study of vericiguat in patients with a recent episode of HFrEF decompensation with RCTs on the evaluation of the effects of drugs that are part of standard therapy. |
| format | Article |
| id | doaj-art-0f22931e43f64708be53e271690f83b9 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2023-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-0f22931e43f64708be53e271690f83b92025-08-20T03:43:40Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202023-06-0128510.15829/1560-4071-2023-54223809Modern approaches to interpretation of clinical trial results to evaluate the effectiveness of heart failure therapy. Analysis of the results of randomized trials PARADIGM-HF, DAPA-HF, EMPEROR-Reduced and VICTORIAS. R. Gilyarevsky0Yu. V. Mareev1Russian Medical Academy of Continuing Professional EducationNational Medical Research Center for Preventive MedicineThe article discusses the results of modern studies evaluating the effectiveness of drug therapy for heart failure with reduced ejection fraction (HFrEF). Modern approaches to a comprehensive evaluation of data obtained in various randomized clinical trials (RCTs) are presented. The role of methods for presenting the RCT results is considered, as well as the difference between hazard ratio and relative risk is clarified. Expert opinions are discussed about the limitations of simplified approaches to comparing the results of large RCTs, which are based only on comparisons of hazard ratio without taking consideration of patient characteristics, study duration, and the absolute number of adverse outcomes that developed. Information is provided on the role of accounting for multiple comparisons in assessing clinical outcomes in RCTs. The article compares the VICTORIA results on the study of vericiguat in patients with a recent episode of HFrEF decompensation with RCTs on the evaluation of the effects of drugs that are part of standard therapy.https://russjcardiol.elpub.ru/jour/article/view/5422heart failureevaluation of research resultsvericiguatcomparison of research results |
| spellingShingle | S. R. Gilyarevsky Yu. V. Mareev Modern approaches to interpretation of clinical trial results to evaluate the effectiveness of heart failure therapy. Analysis of the results of randomized trials PARADIGM-HF, DAPA-HF, EMPEROR-Reduced and VICTORIA Российский кардиологический журнал heart failure evaluation of research results vericiguat comparison of research results |
| title | Modern approaches to interpretation of clinical trial results to evaluate the effectiveness of heart failure therapy. Analysis of the results of randomized trials PARADIGM-HF, DAPA-HF, EMPEROR-Reduced and VICTORIA |
| title_full | Modern approaches to interpretation of clinical trial results to evaluate the effectiveness of heart failure therapy. Analysis of the results of randomized trials PARADIGM-HF, DAPA-HF, EMPEROR-Reduced and VICTORIA |
| title_fullStr | Modern approaches to interpretation of clinical trial results to evaluate the effectiveness of heart failure therapy. Analysis of the results of randomized trials PARADIGM-HF, DAPA-HF, EMPEROR-Reduced and VICTORIA |
| title_full_unstemmed | Modern approaches to interpretation of clinical trial results to evaluate the effectiveness of heart failure therapy. Analysis of the results of randomized trials PARADIGM-HF, DAPA-HF, EMPEROR-Reduced and VICTORIA |
| title_short | Modern approaches to interpretation of clinical trial results to evaluate the effectiveness of heart failure therapy. Analysis of the results of randomized trials PARADIGM-HF, DAPA-HF, EMPEROR-Reduced and VICTORIA |
| title_sort | modern approaches to interpretation of clinical trial results to evaluate the effectiveness of heart failure therapy analysis of the results of randomized trials paradigm hf dapa hf emperor reduced and victoria |
| topic | heart failure evaluation of research results vericiguat comparison of research results |
| url | https://russjcardiol.elpub.ru/jour/article/view/5422 |
| work_keys_str_mv | AT srgilyarevsky modernapproachestointerpretationofclinicaltrialresultstoevaluatetheeffectivenessofheartfailuretherapyanalysisoftheresultsofrandomizedtrialsparadigmhfdapahfemperorreducedandvictoria AT yuvmareev modernapproachestointerpretationofclinicaltrialresultstoevaluatetheeffectivenessofheartfailuretherapyanalysisoftheresultsofrandomizedtrialsparadigmhfdapahfemperorreducedandvictoria |