Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites.

Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites.

Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiable signatures of balancing selection. To comprehensively survey for genes under such selection in the human malaria parasite Plasmodium falciparum, we generated paired-end short-read sequences of para...

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Main Authors: Alfred Amambua-Ngwa, Kevin K A Tetteh, Magnus Manske, Natalia Gomez-Escobar, Lindsay B Stewart, M Elizabeth Deerhake, Ian H Cheeseman, Christopher I Newbold, Anthony A Holder, Ellen Knuepfer, Omar Janha, Muminatou Jallow, Susana Campino, Bronwyn Macinnis, Dominic P Kwiatkowski, David J Conway
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002992&type=printable
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