The impact of kidney function on Alzheimer’s disease blood biomarkers: implications for predicting amyloid-β positivity

The impact of kidney function on Alzheimer’s disease blood biomarkers: implications for predicting amyloid-β positivity

Abstract Background Impaired kidney function has a potential confounding effect on blood biomarker levels, including biomarkers for Alzheimer’s disease (AD). Given the imminent use of certain blood biomarkers in the routine diagnostic work-up of patients with suspected AD, knowledge on the potential...

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Main Authors: Burak Arslan, Wagner S. Brum, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Kübra Tan, Paolo Vitali, Maxime Montembeault, Jesse Klostranec, Arthur C. Macedo, Cecile Tissot, Serge Gauthier, Juan Lantero-Rodriguez, Eduardo R. Zimmer, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea L. Benedet, Nicholas J. Ashton
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Alzheimer’s Research & Therapy
Subjects:
eGFR
Kidney impairment
Amyloid
p-tau
NfL
GFAP
Online Access:https://doi.org/10.1186/s13195-025-01692-z
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