Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation
Introduction. Helium is a noble gas with low density and increased carbon dioxide (CO2) diffusion capacity. This allows lower driving pressures in mechanical ventilation and increased CO2 diffusion. We hypothesized that heliox facilitates ventilation in patients during lung-protective mechanical ven...
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Wiley
2014-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/954814 |
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| author | Charlotte J. Beurskens Daniel Brevoord Wim K. Lagrand Walter M. van den Bergh Margreeth B. Vroom Benedikt Preckel Janneke Horn Nicole P. Juffermans |
| author_facet | Charlotte J. Beurskens Daniel Brevoord Wim K. Lagrand Walter M. van den Bergh Margreeth B. Vroom Benedikt Preckel Janneke Horn Nicole P. Juffermans |
| author_sort | Charlotte J. Beurskens |
| collection | DOAJ |
| description | Introduction. Helium is a noble gas with low density and increased carbon dioxide (CO2) diffusion capacity. This allows lower driving pressures in mechanical ventilation and increased CO2 diffusion. We hypothesized that heliox facilitates ventilation in patients during lung-protective mechanical ventilation using low tidal volumes. Methods. This is an observational cohort substudy of a single arm intervention study. Twenty-four ICU patients were included, who were admitted after a cardiac arrest and mechanically ventilated for 3 hours with heliox (50% helium; 50% oxygen). A fixed protective ventilation protocol (6 mL/kg) was used, with prospective observation for changes in lung mechanics and gas exchange. Statistics was by Bonferroni post-hoc correction with statistical significance set at P<0.017. Results. During heliox ventilation, respiratory rate decreased (25±4 versus 23±5 breaths min−1, P=0.010). Minute volume ventilation showed a trend to decrease compared to baseline (11.1±1.9 versus 9.9±2.1 L min−1, P=0.026), while reducing PaCO2 levels (5.0±0.6 versus 4.5±0.6 kPa, P=0.011) and peak pressures (21.1±3.3 versus 19.8±3.2 cm H2O, P=0.024). Conclusions. Heliox improved CO2 elimination while allowing reduced minute volume ventilation in adult patients during protective mechanical ventilation. |
| format | Article |
| id | doaj-art-0f0134203aa448a1a6b6a64ed08065a9 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-0f0134203aa448a1a6b6a64ed08065a92025-02-03T01:03:16ZengWileyCritical Care Research and Practice2090-13052090-13132014-01-01201410.1155/2014/954814954814Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical VentilationCharlotte J. Beurskens0Daniel Brevoord1Wim K. Lagrand2Walter M. van den Bergh3Margreeth B. Vroom4Benedikt Preckel5Janneke Horn6Nicole P. Juffermans7Laboratory of Experimental Intensive Care and Anaesthesiology (LEICA), Academic Medical Center, University of Amsterdam, Room M0–210, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsLaboratory of Experimental Intensive Care and Anaesthesiology (LEICA), Academic Medical Center, University of Amsterdam, Room M0–210, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Intensive Care, Academic Medical Center, University of Amsterdam, Room M0–210, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Intensive Care, University Medical Center, Hanzeplein 1, 9713 GZ Groningen, The NetherlandsDepartment of Intensive Care, Academic Medical Center, University of Amsterdam, Room M0–210, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsLaboratory of Experimental Intensive Care and Anaesthesiology (LEICA), Academic Medical Center, University of Amsterdam, Room M0–210, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Intensive Care, University Medical Center, Hanzeplein 1, 9713 GZ Groningen, The NetherlandsLaboratory of Experimental Intensive Care and Anaesthesiology (LEICA), Academic Medical Center, University of Amsterdam, Room M0–210, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsIntroduction. Helium is a noble gas with low density and increased carbon dioxide (CO2) diffusion capacity. This allows lower driving pressures in mechanical ventilation and increased CO2 diffusion. We hypothesized that heliox facilitates ventilation in patients during lung-protective mechanical ventilation using low tidal volumes. Methods. This is an observational cohort substudy of a single arm intervention study. Twenty-four ICU patients were included, who were admitted after a cardiac arrest and mechanically ventilated for 3 hours with heliox (50% helium; 50% oxygen). A fixed protective ventilation protocol (6 mL/kg) was used, with prospective observation for changes in lung mechanics and gas exchange. Statistics was by Bonferroni post-hoc correction with statistical significance set at P<0.017. Results. During heliox ventilation, respiratory rate decreased (25±4 versus 23±5 breaths min−1, P=0.010). Minute volume ventilation showed a trend to decrease compared to baseline (11.1±1.9 versus 9.9±2.1 L min−1, P=0.026), while reducing PaCO2 levels (5.0±0.6 versus 4.5±0.6 kPa, P=0.011) and peak pressures (21.1±3.3 versus 19.8±3.2 cm H2O, P=0.024). Conclusions. Heliox improved CO2 elimination while allowing reduced minute volume ventilation in adult patients during protective mechanical ventilation.http://dx.doi.org/10.1155/2014/954814 |
| spellingShingle | Charlotte J. Beurskens Daniel Brevoord Wim K. Lagrand Walter M. van den Bergh Margreeth B. Vroom Benedikt Preckel Janneke Horn Nicole P. Juffermans Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation Critical Care Research and Practice |
| title | Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation |
| title_full | Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation |
| title_fullStr | Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation |
| title_full_unstemmed | Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation |
| title_short | Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation |
| title_sort | heliox improves carbon dioxide removal during lung protective mechanical ventilation |
| url | http://dx.doi.org/10.1155/2014/954814 |
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