Ultrasensitive photoelectrochemical immunosensor based on floral cluster SnS2/ZnCdS heterostructure for the detection of CA199
The early and accurate detection of tumor markers is crucial for cancer diagnosis, prognosis, and treatment monitoring. Carbohydrate antigen 199 (CA199), as a key biomarker of pancreatic, gastric, and colorectal cancers, is widely used in the clinical management. The development of sensitive, rapid...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1584456/full |
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| _version_ | 1850125587585171456 |
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| author | Hui Zhou Qingqing Guo Xin Zhang Tingting Chu Wen Zhang Qing Liu Linlin Cao |
| author_facet | Hui Zhou Qingqing Guo Xin Zhang Tingting Chu Wen Zhang Qing Liu Linlin Cao |
| author_sort | Hui Zhou |
| collection | DOAJ |
| description | The early and accurate detection of tumor markers is crucial for cancer diagnosis, prognosis, and treatment monitoring. Carbohydrate antigen 199 (CA199), as a key biomarker of pancreatic, gastric, and colorectal cancers, is widely used in the clinical management. The development of sensitive, rapid and cost-effective detection methods for CA199 is of paramount importance in improving early detection rates and patient outcomes. In this study, we present a novel photoelectrochemical (PEC) immunosensor based on a SnS2/ZnCdS heterostructure designed for the ultrasensitive detection of CA199. The unique heterojunction between SnS2 and ZnCdS enhances photocurrent generation by effectively suppressing charge recombination and improving charge separation. Furthermore, the flower-like morphology of the heterostructure further boosts light absorption and photogenerated carrier transport, resulting in significantly enhanced sensor performance. This label-free PEC immunosensor exhibits outstanding stability, reproducibility and selectivity, with a broad detection range from 0.01 to 1000 U/mL and an ultra-low detection limit of 1.00 × 10−3 U/mL. These features demonstrate the potential of this sensor as a powerful tool for sensitive CA199 detection, offering promising applications in cancer diagnostics and monitoring. |
| format | Article |
| id | doaj-art-0f005fb70b7e4ecca6c47761d003abd8 |
| institution | OA Journals |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-0f005fb70b7e4ecca6c47761d003abd82025-08-20T02:34:06ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-06-011310.3389/fbioe.2025.15844561584456Ultrasensitive photoelectrochemical immunosensor based on floral cluster SnS2/ZnCdS heterostructure for the detection of CA199Hui Zhou0Qingqing Guo1Xin Zhang2Tingting Chu3Wen Zhang4Qing Liu5Linlin Cao6Zibo Central Hospital Affiliated to Binzhou Medical University, Zibo, Shandong, ChinaPKUCare Luzhong Hospital, Zibo, Shandong, ChinaZibo Central Hospital Affiliated to Binzhou Medical University, Zibo, Shandong, ChinaZibo Central Hospital Affiliated to Binzhou Medical University, Zibo, Shandong, ChinaZibo Central Hospital Affiliated to Binzhou Medical University, Zibo, Shandong, ChinaSchool of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, ChinaZibo Central Hospital Affiliated to Binzhou Medical University, Zibo, Shandong, ChinaThe early and accurate detection of tumor markers is crucial for cancer diagnosis, prognosis, and treatment monitoring. Carbohydrate antigen 199 (CA199), as a key biomarker of pancreatic, gastric, and colorectal cancers, is widely used in the clinical management. The development of sensitive, rapid and cost-effective detection methods for CA199 is of paramount importance in improving early detection rates and patient outcomes. In this study, we present a novel photoelectrochemical (PEC) immunosensor based on a SnS2/ZnCdS heterostructure designed for the ultrasensitive detection of CA199. The unique heterojunction between SnS2 and ZnCdS enhances photocurrent generation by effectively suppressing charge recombination and improving charge separation. Furthermore, the flower-like morphology of the heterostructure further boosts light absorption and photogenerated carrier transport, resulting in significantly enhanced sensor performance. This label-free PEC immunosensor exhibits outstanding stability, reproducibility and selectivity, with a broad detection range from 0.01 to 1000 U/mL and an ultra-low detection limit of 1.00 × 10−3 U/mL. These features demonstrate the potential of this sensor as a powerful tool for sensitive CA199 detection, offering promising applications in cancer diagnostics and monitoring.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1584456/fullSnS2/ZnCdSflower-like morphologyheterojunctionphotoelectrochemical immunosensorCA199 |
| spellingShingle | Hui Zhou Qingqing Guo Xin Zhang Tingting Chu Wen Zhang Qing Liu Linlin Cao Ultrasensitive photoelectrochemical immunosensor based on floral cluster SnS2/ZnCdS heterostructure for the detection of CA199 Frontiers in Bioengineering and Biotechnology SnS2/ZnCdS flower-like morphology heterojunction photoelectrochemical immunosensor CA199 |
| title | Ultrasensitive photoelectrochemical immunosensor based on floral cluster SnS2/ZnCdS heterostructure for the detection of CA199 |
| title_full | Ultrasensitive photoelectrochemical immunosensor based on floral cluster SnS2/ZnCdS heterostructure for the detection of CA199 |
| title_fullStr | Ultrasensitive photoelectrochemical immunosensor based on floral cluster SnS2/ZnCdS heterostructure for the detection of CA199 |
| title_full_unstemmed | Ultrasensitive photoelectrochemical immunosensor based on floral cluster SnS2/ZnCdS heterostructure for the detection of CA199 |
| title_short | Ultrasensitive photoelectrochemical immunosensor based on floral cluster SnS2/ZnCdS heterostructure for the detection of CA199 |
| title_sort | ultrasensitive photoelectrochemical immunosensor based on floral cluster sns2 zncds heterostructure for the detection of ca199 |
| topic | SnS2/ZnCdS flower-like morphology heterojunction photoelectrochemical immunosensor CA199 |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1584456/full |
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