Akkermansia muciniphila ameliorates olanzapine-induced metabolic dysfunction-associated steatotic liver disease via PGRMC1/SIRT1/FOXO1 signaling pathway

Akkermansia muciniphila ameliorates olanzapine-induced metabolic dysfunction-associated steatotic liver disease via PGRMC1/SIRT1/FOXO1 signaling pathway

Akkermansia muciniphila (AKK), classified as “lean bacteria,” has emerged as a promising candidate for ameliorating metabolic disorders, including obesity, diabetes, and liver disease. In this study, we investigated the therapeutic potential of AKK to counteract metabolic dysfunctions induced by Ola...

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Bibliographic Details
Main Authors: Hui Chen, Ting Cao, ChenQuan Lin, ShiMeng Jiao, YiFang He, ZhenYu Zhu, QiuJin Guo, RenRong Wu, HuaLin Cai, BiKui Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
AKK
OLZ
MASLD
lipid accumulation
insulin resistance
PGRMC1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1550015/full
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