Linking the low‐density lipoprotein receptor‐binding segment enables the therapeutic 5‐YHEDA peptide to cross the blood‐brain barrier and scavenge excess iron and radicals in the brain of senescent mice

Linking the low‐density lipoprotein receptor‐binding segment enables the therapeutic 5‐YHEDA peptide to cross the blood‐brain barrier and scavenge excess iron and radicals in the brain of senescent mice

Abstract Introduction Iron accumulates in the brain during aging, which catalyzes radical formation, causing neuronal impairment, and is thus considered a pathogenic factor in Alzheimer's disease (AD). To scavenge excess iron‐catalyzed radicals and thereby protect the brain and decrease the inc...

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Main Authors: Zhenyou Zou, Shengxi Shao, Ruyi Zou, Jini Qi, Liguan Chen, Hui Zhang, Qiqiong Shen, Yue Yang, Liman Ma, Ruzeng Guo, Hongwen Li, Haibo Tian, Pengxin Li, Mingfang Yu, Lu Wang, Wenjuan Kong, Caiyu Li, Zhenhai Yu, Yuping Huang, Li Chen, Qi Shao, Xinyan Gao, Xiaolin Chen, Zhengbo Zhang, Jianguo Yan, Xiaoyun Shao, Ru Pan, Lu Xu, Jing Fang, Lei Zhao, Yaohui Huang, Anqi Li, Yuchong Zhang, Wenkao Huang, Kechun Tian, Minxin Hu, Linchao Xie, Lingbin Wu, Yu Wu, Zhen Luo, Wenxin Xiao, Shanshan Ma, Jianan Wang, Kaixin Huang, Siyuan He, Fan Yang, Shuni Zhou, Mo Jia, Hongsheng Lu, Xinjuan Wang, Jie Tan
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Alzheimer's disease
Senescent mouse
bs‐5‐YHEDA
Blood‐brain barrier
LDLR
ApoB‐100
Online Access:https://doi.org/10.1016/j.trci.2019.07.013
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