Treatment of overactive bladder symptoms in women with Diunorm®: preliminary results report
Introduction. Overactive bladder (OAB) with or without urgent incontinence tends to progress with age and occurs in both men and women. However, the frequency of occurrence in the female population averages about 25%.Purpose of the study. To assess the effectiveness and safety of the drug Diunorm® (...
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Ministry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional Education
2021-07-01
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| Series: | Вестник урологии |
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| Online Access: | https://www.urovest.ru/jour/article/view/451 |
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| author | S. V. Shkodkin M. V. Pokrovsky S. S. Krasnyak A. V. Polichuk S. V. Chirkov O. V. Churikova N. A. Kpavtsova |
| author_facet | S. V. Shkodkin M. V. Pokrovsky S. S. Krasnyak A. V. Polichuk S. V. Chirkov O. V. Churikova N. A. Kpavtsova |
| author_sort | S. V. Shkodkin |
| collection | DOAJ |
| description | Introduction. Overactive bladder (OAB) with or without urgent incontinence tends to progress with age and occurs in both men and women. However, the frequency of occurrence in the female population averages about 25%.Purpose of the study. To assess the effectiveness and safety of the drug Diunorm® (in caps.) in the prevention and treatment of OAB in women.Materials and methods. The statistical analysis includes the results of a survey of 28 women with symptoms of OAB, whose average age was 35.3 years. The drug Diunorm® was used for treatment in dosage 400 mg QD for 90 days. Patients completed the Overactive Bladder Awareness Tool and a urination diary. Additionally, urinalysis, bacteriological examination of urine, uroflowmetry, bladder ultrasound and cystoscopy were performed.Results. All women throughout the study had negative urine cultures and no pyuria in urinalysis, which excluded an infectious etiology of urinary dysfunction. During therapy, a statistically significant decrease in irritative symptoms was recorded according to the Overactive Bladder Awareness Tool questionnaire. The sum of points after 1 and 3 mo decreased by 3.0 and 4.3 points, respectively (p < 0.05). Positive dynamics in terms of the points' sum was noted in 75%, in relation to nocturia in 82% of patients (p < 0.01). The average urination rate increased from 13.3 ± 0.7 ml/s to 15.1 ± 0.7 ml/s and 15.4 ± 0.5 ml/s after 1.5 and 3 months, respectively (p < 0,0001). A similar trend was observed for maximum urine flow and residual urine volume. The maximum urine flow when taking Diunorm® increased from 15.9 ± 0.6 ml/s to 17.4 ± 0.5 ml/s and 18.1 ± 0.4 ml/s (p < 0.001). Residual urine volume decreased throughout the study. When included in the study, after 1,5 and 3 mo, this indicator was 19.9 ± 1.4; 12.2 ± 1.6 and 6.4 ± 1.1 ml, respectively (p < 0.001).Conclusion. Diunorm® can become a worthy alternative to traditional first-line OAB therapy. Comparative studies are required to obtain a high-level evidence base. |
| format | Article |
| id | doaj-art-0ef788319dce438cb86e4208d7f16059 |
| institution | Kabale University |
| issn | 2308-6424 |
| language | Russian |
| publishDate | 2021-07-01 |
| publisher | Ministry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional Education |
| record_format | Article |
| series | Вестник урологии |
| spelling | doaj-art-0ef788319dce438cb86e4208d7f160592025-08-20T03:57:12ZrusMinistry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional EducationВестник урологии2308-64242021-07-019210011010.21886/2308-6424-2021-9-2-100-110315Treatment of overactive bladder symptoms in women with Diunorm®: preliminary results reportS. V. Shkodkin0M. V. Pokrovsky1S. S. Krasnyak2A. V. Polichuk3S. V. Chirkov4O. V. Churikova5N. A. Kpavtsova6St. Joasaph Belgorod Regional Clinical Hospital; Belgorod State National Research UniversityBelgorod State National Research UniversityN.A.Lopatkin Scientific Research Institute of Urology and Interventional Radiology -branch of the National Medical Research Radiological CenterBelgorod State National Research University; «Dr. Fomin's Medical Center - Belgorod»Belgorod State National Research University; St. Luke of Crimea Stariy Oskol District HospitalBelgorod State National Research University; «Promedika» Medical Centre, Ltd.«Energy of Life» Clinical and Diagnostic Centre, Ltd.Introduction. Overactive bladder (OAB) with or without urgent incontinence tends to progress with age and occurs in both men and women. However, the frequency of occurrence in the female population averages about 25%.Purpose of the study. To assess the effectiveness and safety of the drug Diunorm® (in caps.) in the prevention and treatment of OAB in women.Materials and methods. The statistical analysis includes the results of a survey of 28 women with symptoms of OAB, whose average age was 35.3 years. The drug Diunorm® was used for treatment in dosage 400 mg QD for 90 days. Patients completed the Overactive Bladder Awareness Tool and a urination diary. Additionally, urinalysis, bacteriological examination of urine, uroflowmetry, bladder ultrasound and cystoscopy were performed.Results. All women throughout the study had negative urine cultures and no pyuria in urinalysis, which excluded an infectious etiology of urinary dysfunction. During therapy, a statistically significant decrease in irritative symptoms was recorded according to the Overactive Bladder Awareness Tool questionnaire. The sum of points after 1 and 3 mo decreased by 3.0 and 4.3 points, respectively (p < 0.05). Positive dynamics in terms of the points' sum was noted in 75%, in relation to nocturia in 82% of patients (p < 0.01). The average urination rate increased from 13.3 ± 0.7 ml/s to 15.1 ± 0.7 ml/s and 15.4 ± 0.5 ml/s after 1.5 and 3 months, respectively (p < 0,0001). A similar trend was observed for maximum urine flow and residual urine volume. The maximum urine flow when taking Diunorm® increased from 15.9 ± 0.6 ml/s to 17.4 ± 0.5 ml/s and 18.1 ± 0.4 ml/s (p < 0.001). Residual urine volume decreased throughout the study. When included in the study, after 1,5 and 3 mo, this indicator was 19.9 ± 1.4; 12.2 ± 1.6 and 6.4 ± 1.1 ml, respectively (p < 0.001).Conclusion. Diunorm® can become a worthy alternative to traditional first-line OAB therapy. Comparative studies are required to obtain a high-level evidence base.https://www.urovest.ru/jour/article/view/451overactive bladder (oab)herbal medicinelower urinary tract symptoms (luts)nocturia |
| spellingShingle | S. V. Shkodkin M. V. Pokrovsky S. S. Krasnyak A. V. Polichuk S. V. Chirkov O. V. Churikova N. A. Kpavtsova Treatment of overactive bladder symptoms in women with Diunorm®: preliminary results report Вестник урологии overactive bladder (oab) herbal medicine lower urinary tract symptoms (luts) nocturia |
| title | Treatment of overactive bladder symptoms in women with Diunorm®: preliminary results report |
| title_full | Treatment of overactive bladder symptoms in women with Diunorm®: preliminary results report |
| title_fullStr | Treatment of overactive bladder symptoms in women with Diunorm®: preliminary results report |
| title_full_unstemmed | Treatment of overactive bladder symptoms in women with Diunorm®: preliminary results report |
| title_short | Treatment of overactive bladder symptoms in women with Diunorm®: preliminary results report |
| title_sort | treatment of overactive bladder symptoms in women with diunorm r preliminary results report |
| topic | overactive bladder (oab) herbal medicine lower urinary tract symptoms (luts) nocturia |
| url | https://www.urovest.ru/jour/article/view/451 |
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