Cytoplasmic HMGB1 promotes the activation of JAK2-STAT3 signaling and PD-L1 expression in breast cancer

Cytoplasmic HMGB1 promotes the activation of JAK2-STAT3 signaling and PD-L1 expression in breast cancer

Abstract Background High-mobility group box 1 (HMGB1) plays various roles depending on its subcellular localization. Extracellular HMGB1 interacts with receptors, such as toll-like receptor 4 and receptor for advanced glycation end products (RAGE), promoting cell proliferation, survival, and migrati...

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Bibliographic Details
Main Authors: Ju-Young Han, Woo Joong Rhee, Jeon-Soo Shin
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Breast cancer
HMGB1
JAK2
PD-L1
STAT3
Online Access:https://doi.org/10.1186/s10020-025-01235-0
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