Bacteriostatic activity and mechanism of minerals containing rubidium
Abstract. Background. Metals and their ions have been used to reduce bacterial infection risks. Among them, minerals containing rubidium (MCR), natural minerals containing metal ions, show potential as novel and tunable materials. Objective. This study aimed to investigate the antibacterial activity...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2025-06-01
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| Series: | Science of Traditional Chinese Medicine |
| Online Access: | http://journals.lww.com/10.1097/st9.0000000000000064 |
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| author | Yucui Lu Xianmei Long Yuanhui Mao Lijing Wang Xiayun Liao Lichun Zhao |
| author_facet | Yucui Lu Xianmei Long Yuanhui Mao Lijing Wang Xiayun Liao Lichun Zhao |
| author_sort | Yucui Lu |
| collection | DOAJ |
| description | Abstract. Background. Metals and their ions have been used to reduce bacterial infection risks. Among them, minerals containing rubidium (MCR), natural minerals containing metal ions, show potential as novel and tunable materials.
Objective. This study aimed to investigate the antibacterial activity and mechanism of MCR.
Methods. The inhibitory effect of MCR on bacteria was clarified using the growth curve method, turbidimetric method, and minimum inhibitory concentration method. Physiological and biochemical indices were employed to investigate the inhibitory mechanism of MCR.
Results. The results revealed that MCR inhibited Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli with minimum inhibitory concentrations of 11.95, 2.60, and 2.60 mg/mL, respectively. The inhibitory activity of MCR was insignificant against Bacillus subtilis, Salmonella typhimurium, and Helicobacter pylori at 3.25 mg/mL. Mechanistic assessments showed that MCR affected bacterial conductivity, protein and nucleic acid levels, reducing sugar content, respiratory chain dehydrogenase activity, bacterial lipid peroxidation, intracellular adenosine triphosphate, and extracellular alkaline phosphatase.
Conclusion. MCR has bacteriostatic activity and the mechanism primarily involves adhesion to bacteria, disrupting the integrity of their cell walls and membranes, and altering their permeability. This disruption leads to the release of intracellular molecules of various sizes, inhibiting cellular respiration and metabolism, and causing oxidative damage. These combined effects impair cellular functions, affecting cell growth and metabolism, or leading to cell death. These findings provide a theoretical reference for the development of MCR as a bacteriostatic agent. |
| format | Article |
| id | doaj-art-0ef5abb53ef54c628cd9f2d7936e7334 |
| institution | Kabale University |
| issn | 2836-922X 2836-9211 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Science of Traditional Chinese Medicine |
| spelling | doaj-art-0ef5abb53ef54c628cd9f2d7936e73342025-08-20T03:33:27ZengWolters Kluwer Health/LWWScience of Traditional Chinese Medicine2836-922X2836-92112025-06-013213714410.1097/st9.0000000000000064202506000-00004Bacteriostatic activity and mechanism of minerals containing rubidiumYucui Lu0Xianmei Long1Yuanhui Mao2Lijing Wang3Xiayun Liao4Lichun Zhao5a College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, Chinac Institute of Traditional Chinese and Zhuang-Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning, Chinac Institute of Traditional Chinese and Zhuang-Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning, Chinab College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Chinab College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Chinaa College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaAbstract. Background. Metals and their ions have been used to reduce bacterial infection risks. Among them, minerals containing rubidium (MCR), natural minerals containing metal ions, show potential as novel and tunable materials. Objective. This study aimed to investigate the antibacterial activity and mechanism of MCR. Methods. The inhibitory effect of MCR on bacteria was clarified using the growth curve method, turbidimetric method, and minimum inhibitory concentration method. Physiological and biochemical indices were employed to investigate the inhibitory mechanism of MCR. Results. The results revealed that MCR inhibited Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli with minimum inhibitory concentrations of 11.95, 2.60, and 2.60 mg/mL, respectively. The inhibitory activity of MCR was insignificant against Bacillus subtilis, Salmonella typhimurium, and Helicobacter pylori at 3.25 mg/mL. Mechanistic assessments showed that MCR affected bacterial conductivity, protein and nucleic acid levels, reducing sugar content, respiratory chain dehydrogenase activity, bacterial lipid peroxidation, intracellular adenosine triphosphate, and extracellular alkaline phosphatase. Conclusion. MCR has bacteriostatic activity and the mechanism primarily involves adhesion to bacteria, disrupting the integrity of their cell walls and membranes, and altering their permeability. This disruption leads to the release of intracellular molecules of various sizes, inhibiting cellular respiration and metabolism, and causing oxidative damage. These combined effects impair cellular functions, affecting cell growth and metabolism, or leading to cell death. These findings provide a theoretical reference for the development of MCR as a bacteriostatic agent.http://journals.lww.com/10.1097/st9.0000000000000064 |
| spellingShingle | Yucui Lu Xianmei Long Yuanhui Mao Lijing Wang Xiayun Liao Lichun Zhao Bacteriostatic activity and mechanism of minerals containing rubidium Science of Traditional Chinese Medicine |
| title | Bacteriostatic activity and mechanism of minerals containing rubidium |
| title_full | Bacteriostatic activity and mechanism of minerals containing rubidium |
| title_fullStr | Bacteriostatic activity and mechanism of minerals containing rubidium |
| title_full_unstemmed | Bacteriostatic activity and mechanism of minerals containing rubidium |
| title_short | Bacteriostatic activity and mechanism of minerals containing rubidium |
| title_sort | bacteriostatic activity and mechanism of minerals containing rubidium |
| url | http://journals.lww.com/10.1097/st9.0000000000000064 |
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