Intestinal barrier damage caused by addictive substance use disorder
Abstract Addictive substance use disorder has a wide range of effects on the intestinal barrier, including damage to the biological, chemical, mechanical, and immune barriers. Damage to the intestinal barrier caused by addictive substance use disorder allows harmful substances and bacteria to cross...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02446-1 |
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| author | Yan Gao Deshenyue Kong Jia-xue Sun Zhong-xu Ma Guang-qing Wang Xing-feng Ma Liang Sun Hua-you Luo Yu Xu Kun-hua Wang |
| author_facet | Yan Gao Deshenyue Kong Jia-xue Sun Zhong-xu Ma Guang-qing Wang Xing-feng Ma Liang Sun Hua-you Luo Yu Xu Kun-hua Wang |
| author_sort | Yan Gao |
| collection | DOAJ |
| description | Abstract Addictive substance use disorder has a wide range of effects on the intestinal barrier, including damage to the biological, chemical, mechanical, and immune barriers. Damage to the intestinal barrier caused by addictive substance use disorder allows harmful substances and bacteria to cross the intestinal barrier into the circulatory system, leading to systemic inflammatory responses and immune imbalances. In addition, the interaction between the gut flora and the central nervous system is recognized as an important component of the gut–brain axis. Gut barrier damage leads to dysbiosis, which in turn affects brain function by activating immune cells and releasing inflammatory factors. This may lead to altered mood and cognitive function, increased addictive substance cravings, and dependence. Recent research has indicated that reshaping the gut–brain axis and adjusting the composition and abundance of gut microbiota holds promise in alleviating withdrawal symptoms with addictive substance dependence. This article reviews the effects of addictive substance use disorder on the intestinal barrier and explores the possibility of improving addictive substance dependence by treating gut barrier damage. |
| format | Article |
| id | doaj-art-0ef52e5562a84d2aa389c724fd1ea465 |
| institution | OA Journals |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-0ef52e5562a84d2aa389c724fd1ea4652025-08-20T01:53:16ZengBMCEuropean Journal of Medical Research2047-783X2025-04-0130111110.1186/s40001-025-02446-1Intestinal barrier damage caused by addictive substance use disorderYan Gao0Deshenyue Kong1Jia-xue Sun2Zhong-xu Ma3Guang-qing Wang4Xing-feng Ma5Liang Sun6Hua-you Luo7Yu Xu8Kun-hua Wang9Yunnan Technological Innovation Centre of Drug Addiction Medicine, Yunnan UniversityYunnan Technological Innovation Centre of Drug Addiction Medicine, Yunnan UniversityYunnan Technological Innovation Centre of Drug Addiction Medicine, Yunnan UniversityThird People’s Hospital of Kunming CityDrug Rehabilitation Administration of Yunnan ProvinceDrug Rehabilitation Administration of Yunnan ProvinceDepartment of Gastrointestinal and Hernia Surgery, First Affiliated Hospital of Kunming Medical UniversityDepartment of Gastrointestinal and Hernia Surgery, First Affiliated Hospital of Kunming Medical UniversityYunnan Technological Innovation Centre of Drug Addiction Medicine, Yunnan UniversityYunnan Technological Innovation Centre of Drug Addiction Medicine, Yunnan UniversityAbstract Addictive substance use disorder has a wide range of effects on the intestinal barrier, including damage to the biological, chemical, mechanical, and immune barriers. Damage to the intestinal barrier caused by addictive substance use disorder allows harmful substances and bacteria to cross the intestinal barrier into the circulatory system, leading to systemic inflammatory responses and immune imbalances. In addition, the interaction between the gut flora and the central nervous system is recognized as an important component of the gut–brain axis. Gut barrier damage leads to dysbiosis, which in turn affects brain function by activating immune cells and releasing inflammatory factors. This may lead to altered mood and cognitive function, increased addictive substance cravings, and dependence. Recent research has indicated that reshaping the gut–brain axis and adjusting the composition and abundance of gut microbiota holds promise in alleviating withdrawal symptoms with addictive substance dependence. This article reviews the effects of addictive substance use disorder on the intestinal barrier and explores the possibility of improving addictive substance dependence by treating gut barrier damage.https://doi.org/10.1186/s40001-025-02446-1Addictive substance use disorderIntestinal barrierGut floraThe gut–brain axis |
| spellingShingle | Yan Gao Deshenyue Kong Jia-xue Sun Zhong-xu Ma Guang-qing Wang Xing-feng Ma Liang Sun Hua-you Luo Yu Xu Kun-hua Wang Intestinal barrier damage caused by addictive substance use disorder European Journal of Medical Research Addictive substance use disorder Intestinal barrier Gut flora The gut–brain axis |
| title | Intestinal barrier damage caused by addictive substance use disorder |
| title_full | Intestinal barrier damage caused by addictive substance use disorder |
| title_fullStr | Intestinal barrier damage caused by addictive substance use disorder |
| title_full_unstemmed | Intestinal barrier damage caused by addictive substance use disorder |
| title_short | Intestinal barrier damage caused by addictive substance use disorder |
| title_sort | intestinal barrier damage caused by addictive substance use disorder |
| topic | Addictive substance use disorder Intestinal barrier Gut flora The gut–brain axis |
| url | https://doi.org/10.1186/s40001-025-02446-1 |
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